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Submit ReviewOrg 37684
Description: 5-HT2 agonist
Chemical Name: (3S)-3-[(2,3--Dihydro-5-methoxy-1H-inden-4-yl)oxy]pyrrolidine hydrochloride
Biological Activity for Org 37684
Org 37684 is an agonist of 5-HT2 receptors. Exhibits a rank order of potency of 5-HT2C >5-HT2B >5-HT2A (pEC50 values are 8.17, 7.96 and 7.11 respectively, in transfected CHO-K1 cells).
Technical Data for Org 37684
| M. Wt | 269.77 |
| Formula | C14H19NO2.HCl |
| Storage | Desiccate at RT |
| CAS Number | 213007-95-5 |
| PubChem ID | 9881884 |
| InChI Key | KJEAKWPQCIAVGR-MERQFXBCSA-N |
| Smiles | COC1=CC=C(CCC3)C3=C1O[C@H]2CCNC2.Cl |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for Org 37684
References for Org 37684
References are publications that support the biological activity of the product.
Porter et al (1999) Functional characterization of agonists at recombinant human 5-HT2A, 5-HT2B and 5-HT2C receptors in CHO-K1 cells. Br.J.Pharmacol. 128 13 PMID: 10498829
De Vry and Schreiber (2000) Effects of selected serotonin 5-HT1 and 5-HT2 receptor agonists on feeding behavior: possible mechanisms of action. Neurosci.Biobehav.Rev. 24 341 PMID: 10781694
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Keywords: Org 37684, Org 37684 supplier, Org37684, 5-HT2, 5-HT2C, agonists, serotonergic, serotonin, Non-selective, 4797, Tocris Bioscience
Citations for Org 37684
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Currently there are no citations for Org 37684.
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Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
5-HT Receptors Scientific Review
Written by Nicholas M. Barnes and John F. Neumaier, this review summarizes the various serotonin receptor subtypes and their importance in mediating the role of serotonin in numerous physiological and pharmacological processes. Compounds available from Tocris are listed.