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OX 04528

Cat. No. 8131 Submit a Review Datasheet / COA / SDS
Pricing Availability   Qty
Description: Highly potent and selective GPR84 agonist
Chemical Name: 3-(3-(3,5-Bis(trifluoromethyl)phenyl)propyl)-5-hydroxypyridine-1-oxide
Purity: ≥98% (HPLC)
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Biological Activity Technical Data Solubility Calculators Datasheets References

Biological Activity for OX 04528

OX 04528 is a highly potent and selective GPR84 agonist. It inhibits cAMP production in CHO cells expressing human GPR84 (EC50 = 6 pM) and shows no β-arrestin recruitment. Exhibits selectivity for GPR84 over FFA1, FFA4, and CB2 receptors. In vivo, OX 04528 shows a half-life of 58 minutes following oral dosing at 10 mg/kg in mouse pharmacokinetic studies. OX 04528 is orally bioavailable.

Technical Data for OX 04528

M. Wt 365.28
Formula C16H13F6NO2
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 3028055-45-7
PubChem ID 170453166
InChI Key DPLHUGXFERHOJE-UHFFFAOYSA-N
Smiles [O-][N+]1=CC(CCCC2=CC(C(F)(F)F)=CC(C(F)(F)F)=C2)=CC(O)=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for OX 04528

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 36.53 100
ethanol 36.53 100

Preparing Stock Solutions for OX 04528

The following data is based on the product molecular weight 365.28. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.74 mL 13.69 mL 27.38 mL
5 mM 0.55 mL 2.74 mL 5.48 mL
10 mM 0.27 mL 1.37 mL 2.74 mL
50 mM 0.05 mL 0.27 mL 0.55 mL

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References for OX 04528

References are publications that support the biological activity of the product.

Wang et al (2024) Development of highly potent, G-protein pathway biased, selective, and orally bioavailable GPR84 agonists. J.Med.Chem. 67 110 PMID: 38146625

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Citations for OX 04528

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