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Submit ReviewOxotremorine sesquifumarate
Description: Muscarinic agonist
Chemical Name: 1-[4-(1-Pyrrolidinyl)-2-butynyl]-2-pyrrolidinone sesquifumarate
Purity: ≥98% (HPLC)
Biological Activity for Oxotremorine sesquifumarate
Oxotremorine sesquifumarate is a muscarinic agonist.
Technical Data for Oxotremorine sesquifumarate
| M. Wt | 380.4 |
| Formula | C12H18N2O.1.5C4H4O4 |
| Storage | Store at RT |
| Purity | ≥98% (HPLC) |
| CAS Number | 17360-35-9 |
| PubChem ID | 6436473 |
| InChI Key | WLYYOFJEBGHKEC-VQYXCCSOSA-N |
| Smiles | OC(=O)\C=C\C(O)=O.OC(=O)\C=C\C(O)=O.OC(=O)\C=C\C(O)=O.O=C1CCCN1CC#CCN1CCCC1.O=C1CCCN1CC#CCN1CCCC1 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for Oxotremorine sesquifumarate
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| water | 9.51 | 25 | |
| DMSO | 38.04 | 100 |
Preparing Stock Solutions for Oxotremorine sesquifumarate
The following data is based on the product molecular weight 380.4. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.63 mL | 13.14 mL | 26.29 mL |
| 5 mM | 0.53 mL | 2.63 mL | 5.26 mL |
| 10 mM | 0.26 mL | 1.31 mL | 2.63 mL |
| 50 mM | 0.05 mL | 0.26 mL | 0.53 mL |
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Product Datasheets for Oxotremorine sesquifumarate
References for Oxotremorine sesquifumarate
References are publications that support the biological activity of the product.
Fisher et al (1984) Differential stimulation in inositol phospholipid turnover in brain by analogs of oxotremorine. J.Neurochem. 43 1171 PMID: 6088696
Moroi-Fetters et al (1988) Muscarinic receptor-mediated phosphoinositide hydrolysis in the rat retina. J.Pharmacol.Exp.Ther. 246 553 PMID: 2841451
Merck Index 12 7085
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Keywords: Oxotremorine sesquifumarate, Oxotremorine sesquifumarate supplier, Muscarinic, agonist, Receptors, Acetylcholine, ACh, Non-selective, Muscarinics, 0843, Tocris Bioscience
3 Citations for Oxotremorine sesquifumarate
Citations are publications that use Tocris products. Selected citations for Oxotremorine sesquifumarate include:
Deng et al (2013) Label-free cell phenotypic assessment of the biased agonism and efficacy of agonists at the endogenous muscarinic M3 receptors. J Pharmacol Toxicol Methods 68 323 PMID: 23933114
Carneiro et al (2014) Activation of P2Y6 receptors increases the voiding frequency in anaesthetized rats by releasing ATP from the bladder urothelium. Br J Pharmacol 171 3404 PMID: 24697602
Bragança et al (2016) Ion Fluxes through KCa2 (SK) and Cav1 (L-type) Channels Contribute to Chronoselectivity of Adenosine A1 Receptor-Mediated Actions in Spontaneously Beating Rat Atria. Front Pharmacol 7 45 PMID: 27014060
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