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Description: Dynamin-related protein 1 (Drp1) inhibitor; cell-permeable
Purity: ≥95% (HPLC)
Biological Activity for P110
P110 is a dynamin-related protein 1 (Drp1) inhibitor, inhibits Drp1 GTPase activity. Displays no effect on dynamin 1 or other mitochondrial dynamics-related proteins. Inhibits mitochondrial fission, dysfunction and reactive oxygen species (ROS) production in vitro. Reduces programmed cell death and improves cell viability by protecting mitochondrial integrity. Reduces mitochondrial fragmentation and mitochondrial ROS production in mouse model of Parkinson's disease. Cell permeable.
Technical Data for P110
| M. Wt | 2411.8 |
| Formula | C100H179N45O25 |
| Sequence |
YGRKKRRQRRRGGDLLPRGS (Modification: Ser-20 = C-terminal amide) |
| Storage | Store at -20°C |
| Purity | ≥95% (HPLC) |
| CAS Number | 2770267-63-3 |
| InChI Key | TYQHBBMTJWPEDH-VZOPDNRXSA-N |
| Smiles | [H]N[C@H](C(NCC(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(NCC(NCC(N[C@H](C(N[C@H](C(N[C@H](C(N1CCC[C@H]1C(N[C@H](C(NCC(N[C@H](C(N)=O)CO)=O)=O)CCCNC(N)=N)=O)=O)CC(C)C)=O)CC(C)C)=O)CC(O)=O)=O)=O)=O)CCCNC(N)=N)=O)CCCNC(N)=N)=O)CCCNC(N)=N)=O)CCC(N)=O)=O)CCCNC(N)=N)=O)CCCNC(N)=N)=O)CCCCN)=O)CCCCN)=O)CCCNC(N)=N)=O)=O)CC2=CC=C(C=C2)O |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for P110
| Solubility | Soluble to 1 mg/ml in water |
Product Datasheets for P110
References for P110
References are publications that support the biological activity of the product.
Qi et al (2013) A novel Drp1 inhibitor diminishes aberrant mitochondrial fission and neurotoxicity. J.Cell Sci. 126 789 PMID: 23239023
Filichia et al (2016) Inhibition of Drp1 mitochondrial translocation provides neural protection in dopaminergic system in a Parkinson's disease model induced by MPTP. Sci.Rep. 13 32656 PMID: 27619562
If you know of a relevant reference for P110, please let us know.
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Keywords: P110, P110 supplier, dynamin, related, protein, 1, inhibitors, inhibits, mitochondrial, fission, dysfunction, mitochondria, Dynamin, 6897, Tocris Bioscience
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