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Description: Potent antagonist of αvβ3-vitronectin interaction; antiangiogenic
Biological Activity for P11
P11 is a potent antagonist of the integrin αvβ3-vitronectin interaction (IC50 = 25.72 nM). Blocks proliferation and induces apoptosis in HUVECs; antiangiogenic.
Technical Data for P11
| M. Wt | 720.78 |
| Formula | C30H48N12O9 |
| Sequence |
HSDVHK (Modifications: Lys-6 = C-terminal amide) |
| Storage | Store at -20°C |
| CAS Number | 848644-86-0 |
| PubChem ID | 90488969 |
| InChI Key | FSVRGWKWZIRBPC-KESUXUJOSA-N |
| Smiles | [H]N[C@@H](CC1=CNC=N1)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC1=CNC=N1)C(=O)N[C@@H](CCCCN)C(N)=O |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for P11
References for P11
References are publications that support the biological activity of the product.
Lee et al (2004) High-throughput screening of novel peptide inhibitors of an integrin receptor from the hexapeptide library by using a protein microarray chip. J.Biomol.Screen. 9 687 PMID: 15634795
Choi et al (2010) Site-specific inhibition of integrin alpha v beta 3-vitronectin association by a ser-asp-val sequence through an Arg-Gly-Asp-binding site of the integrin. Proteomics 10 72 PMID: 19882657
Bang et al (2011) Pharmacoproteomic analysis of a novel cell-permeable inhibitor of tumor-induced angiogenesis. Mol.Cell Proteomics 10 M110 PMID: 21558493
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Keywords: P11, P11 supplier, integrin, alpha, v, beta, 3, avb3, antagonists, vitronectin, potent, antiangiogenics, angiogenesis, Integrins, Cell, Adhesion, Molecules, Antiangiogenics, 4744, Tocris Bioscience
2 Citations for P11
Citations are publications that use Tocris products. Selected citations for P11 include:
Keasey et al (2018) Blood vitronectin is a major activator of LIF and IL-6 in the brain through integrin-FAK and uPAR signaling. J Cell Sci 131 PMID: 29222114
Visavadiya (2016) Integrin-FAK signaling rapidly and potently promotes mitochondrial function through STAT3. Cell Communication and Signaling 14 32 PMID: 27978828
Reviews for P11
Average Rating: 5 (Based on 2 Reviews.)
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Cell cultures with ECM proteins, integrin blockade and In vitro drug treatments.
By
Anonymous on 03/24/2020
Assay Type: In Vitro
Species: Rat
Cell Line/Tissue: rat astroglioma C6 cells
alpha v beta 3 peptide antagonist P11 10 µg/ml
Mitochondrial bioenergetics measurements by reagent screen.
By
Anonymous on 03/15/2020
Assay Type: In Vitro
Species: Mouse
Cell Line/Tissue: mouse brain endothelioma cell line
10 μg/ml
Literature in this Area
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Angiogenesis in Cancer Poster
This poster summarizes the pathogenesis of angiogenesis in cancer, as well as some of the main angiogenesis therapeutic targets.
