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Description: Protein disulfide isomerase (PDI) inhibitor
Chemical Name: N-[(1,1-Dimethylethoxy)carbonyl]-L-phenylalanyl-O-(ethenylsulfonyl)-N-4-pentyn-1-yl-L-tyrosinamide
Purity: ≥98% (HPLC)
Biological Activity for P1
P1 is a protein disulfide isomerase (PDI) inhibitor (IC50 = 1.7 μM). Inhibits proliferation of numerous cancer cell lines. Cell permeable.
Technical Data for P1
| M. Wt | 583.7 |
| Formula | C30H37N3O7S |
| Storage | Store at -20°C |
| Purity | ≥98% (HPLC) |
| CAS Number | 1461648-55-4 |
| PubChem ID | 91826082 |
| InChI Key | RNMDSOKRNOMQFX-UIOOFZCWSA-N |
| Smiles | O=[C@@](NCCCC#C)[C@@H](NC([C@@H](NC(OC(C)(C)C)=O)CC2=CC=CC=C2)=O)CC1=CC=C(OS(C=C)(=O)=O)C=C1 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for P1
References for P1
References are publications that support the biological activity of the product.
Ge et al (2013) Small molecule probe suitable for in situ profiling and inhibition of protein disulfide isomerase ACS Chem.Biol. 8 2577 PMID: 24070012
Xu et al (2013) Protein disulfide isomerase interacts with tau protein and inhibits its fibrillization. PLoS One 8 e76657 PMID: 24098548
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Keywords: P1, P1 supplier, Protein, disulfide, Isomerase, PDI, inhibitors, inhibits, Disulfide, 5127, Tocris Bioscience
1 Citation for P1
Citations are publications that use Tocris products. Selected citations for P1 include:
Chia-Yi et al (2022) Hyperglycemia exacerbates dengue virus infection by facilitating poly(A)-binding protein-mediated viral translation. JCI Insight 7 PMID: 36125898
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Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
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Gut Hormones Poster
The gastrointestinal tract is the largest endocrine gland in the human body, secreting hormones that affect digestion, appetite and energy expenditure. Neuropeptide modulators and gut hormones that influence appetite are reviewed in this poster.