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Description: Caged nicotine; photoactivated by one-photon and two-photon excitation
Chemical Name: (1S,2S)-1-((7-(Bis(carboxymethyl)amino)-2-oxo-2H-chromen-4-yl)methyl)-1-methyl-2-(pyridin-3-yl)pyrrolidin-1-ium ditrifluoroacetate
Purity: ≥98% (HPLC)
Biological Activity for PA Nic
PA Nic is a coumarin-caged nicotine. Releases nicotine when exposed to 390 ± 10 nm wavelength light (λmax = 404 nm). Suitable for two-photon uncaging at <900 nm (Maximum two-photon cross-section at 810 nm). Extinction coefficient (ε) 17,400 M-1cm-1. Evokes nicotinic currents in mouse brain slices under one and two-photon activation conditions.
Technical Data for PA Nic
| M. Wt | 679.52 |
| Formula | C24H26N3O6.C2F3O2.C2HF3O2 |
| Storage | Store at -20°C |
| Purity | ≥98% (HPLC) |
| Smiles | C[N@@+]1(CC2=CC(OC3=C2C=CC(N(CC(O)=O)CC(O)=O)=C3)=O)CCC[C@H]1C4=CC=CN=C4.OC(C(F)(F)F)=O.[O-]C(C(F)(F)F)=O |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for PA Nic
References for PA Nic
References are publications that support the biological activity of the product.
Banala et al (2018) Photoactivatable drugs for nicotinic optopharmacology. Nat.Methods 15 347 PMID: 29578537
Yan et al (2018) Nicotinic cholinergic receptors in VTA glutamate neurons modulate excitatory transmission. Cell Rep. 23 2236 PMID: 29791835
Arvin et al (2019) Probing nicotinic acetylcholine receptor function in mouse brain slices via laser flash photolysis of photoactivatable nicotine. J.Vis.Exp. 143 e58873 PMID: 30735191
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Keywords: PA Nic, PA Nic supplier, PANic, caged, compounds, photoactivatable, nicotine, nicotinics, cholinergics, agonists, activators, nAChR, Nicotinic, Receptors, (Non-selective), Caged, Compounds, 6700, Tocris Bioscience
Citations for PA Nic
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Currently there are no citations for PA Nic.
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