Submit a Review & Earn an Amazon Gift Card
You can now submit reviews for your favorite Tocris products. Your review will help other researchers decide on the best products for their research. Why not submit a review today?!
Submit ReviewPCA 4248
Discontinued Product
0571 has been discontinued.
View all Platelet-Activating Factor (PAF) Receptors products.
Description: PAF receptor antagonist
Chemical Name: 1,4-Dihydro-2,4,6-trimethyl-3,5-pyridinedicarboxylic acid methyl 2-(phenylthio)ethyl ester
Purity: ≥95%
Biological Activity for PCA 4248
PCA 4248 is a specific PAF antagonist, more potent than the ginkolide BN-52021. Inhibits rabbit platelet aggregation with an IC50 value of 1.05 μM and has no significant activity on Ca2+ channels. Active in vivo, antagonizing PAF-induced systemic hypotension and protein-plasma extravasation in rats.
Technical Data for PCA 4248
| M. Wt | 361.46 |
| Formula | C19H23NO4S |
| Storage | Desiccate at -20°C |
| Purity | ≥95% |
| CAS Number | 123875-01-4 |
| PubChem ID | 4698 |
| InChI Key | DHCNAWNKZMNTIS-UHFFFAOYSA-N |
| Smiles | COC(=O)C1=C(C)NC(C)=C(C1C)C(=O)OCCSC1=CC=CC=C1 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for PCA 4248
References for PCA 4248
References are publications that support the biological activity of the product.
Fernandez-Gallardo et al (1990) Pharmacological actions of PCA 4248, a new platelet-activating factor receptor antagonist: in vivo studies. J.Pharmacol.Exp.Ther. 255 34 PMID: 2170626
Sunkel et al (1990) 4-Alkyl-1,4-dihydropyridine derivatives as specific PAF-acether antagonists. J.Med.Chem. 33 3205 PMID: 2175357
Sunkel et al (1990) 1,4-Dihydropyridines, a new class of platelet activating factor receptor antagonists: in vitro pharmacological studies. J.Pharmacol.Exp.Ther. 255 28 PMID: 2170624
View Related Products by Target
View Related Products by Product Action
View all Platelet-Activating Factor (PAF) Receptor Antagonists
Keywords: PCA 4248, PCA 4248 supplier, PAF, receptor, antagonists, Receptors, Platelet-activating, Factor, PCA4248, (PAF), 0571, Tocris Bioscience
4 Citations for PCA 4248
Citations are publications that use Tocris products. Selected citations for PCA 4248 include:
Hergott et al (2015) Bacterial exploitation of phosphorylcholine mimicry suppresses inflammation to promote airway infection. Mediators Inflamm 125 3878 PMID: 26426079
Garcia et al (2010) Platelet-activating factor receptor plays a role in lung injury and death caused by Influenza A in mice. PLoS Pathog 6 e1001171 PMID: 21079759
Bachi et al (2012) Apoptotic cells contribute to melanoma progression and this effect is partially mediated by the platelet-activating factor receptor. J Pharmacol Exp Ther 2012 610371 PMID: 22577252
Mathison et al (2004) Effects of cannabinoid receptor-2 activation on accelerated gastrointestinal transit in lipopolysaccharide-treated rats. Br J Pharmacol 142 1247 PMID: 15249429
Reviews for PCA 4248
There are currently no reviews for this product. Be the first to review PCA 4248 and earn rewards!
Have you used PCA 4248?
Submit a review and receive an Amazon gift card.
$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image
$25/€18/£15/$25CAN/¥75 Yuan/¥2500 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image