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Submit ReviewPD 144418 oxalate
Discontinued Product
2606 has been discontinued.
Description: High affinity, selective σ1 ligand
Chemical Name: 1,2,3,6-Tetrahydro-5-[3-(4-methylphenyl)-5-isoxazolyl]-1-propylpyridine oxalate
Purity: ≥98% (HPLC)
Biological Activity for PD 144418 oxalate
PD 144418 oxalate is a high affinity, selective σ1 ligand (Ki values are 0.08 and 1377 nM for σ1 and σ2 respectively). Displays no significant activity at a wide range of other receptors, ion channels and enzymes. Antagonizes mescaline-induced scratching in mice following i.p. administration. Also attenuates cocaine-induced hyperactivity in mice.
Licensing Information
Sold for research purposes under agreement from Pfizer Inc.
Compound Libraries for PD 144418 oxalate
PD 144418 oxalate is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.
Technical Data for PD 144418 oxalate
| M. Wt | 372.42 |
| Formula | C18H22N2O.C2H2O4 |
| Storage | Desiccate at RT |
| Purity | ≥98% (HPLC) |
| CAS Number | 1794760-28-3 |
| PubChem ID | 9817231 |
| InChI Key | FOQRKFCLRMMKAT-UHFFFAOYSA-N |
| Smiles | O=C(O)C(O)=O.CCCN1CC(C2=CC(C3=CC=C(C)C=C3)=NO2)=CCC1 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for PD 144418 oxalate
References for PD 144418 oxalate
References are publications that support the biological activity of the product.
Akunne et al (1997) The pharmacology of the novel and selective sigma ligand, PD 144418. Neuropharmacology 36 51 PMID: 9144641
Lever et al (2014) Relationship between cerebral sigma-1 receptor occupancy and attenuation of cocaine's motor stimulatory effects in mice by PD144418. J.Pharmacol.Exp.Ther. 351 153 PMID: 25100754
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Keywords: PD 144418 oxalate, PD 144418 oxalate supplier, High, affinity, selective, σ1, sigma1, ligands, Receptors, PD144418, oxalate, Pfizer, Sigma1, 2606, Tocris Bioscience
2 Citations for PD 144418 oxalate
Citations are publications that use Tocris products. Selected citations for PD 144418 oxalate include:
Navarro et al (2015) Orexin-corticotropin-releasing factor receptor heteromers in the ventral tegmental area as targets for cocaine. Autophagy 35 6639 PMID: 25926444
Sánchez-Blázquez et al (2018) Sigma 1 Receptor Antagonists Inhibit Manic-Like Behaviors in Two Congenital Strains of Mice. Int J Neuropsychopharmacol 21 938 PMID: 29860313
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