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Submit ReviewPD 168568 dihydrochloride
Description: Potent and selective D4 antagonist
Chemical Name: 3-[2-[4-(3,4-dimethylphenyl)-1-piperazinyl]ethyl]-2,3-dihydro-1H-isoindol-1-one dihydrochloride
Purity: ≥98% (HPLC)
Biological Activity for PD 168568 dihydrochloride
PD 168568 dihydrochloride is a potent and selective dopamine D4 receptor antagonist (Ki values are 8.8 and 1842 nM at D4 and D2 receptors respectively). Reverses amphetamine-stimulated locomotion in vivo and is orally active.
Technical Data for PD 168568 dihydrochloride
| M. Wt | 422.39 |
| Formula | C22H27N3O.2HCl |
| Storage | Desiccate at RT |
| Purity | ≥98% (HPLC) |
| CAS Number | 1782532-06-2 |
| PubChem ID | 56972231 |
| InChI Key | RMNWLEGGYCVHFD-UHFFFAOYSA-N |
| Smiles | CC1=C(C)C=CC(N2CCN(CCC(N4)C3=CC=CC=C3C4=O)CC2)=C1.Cl.Cl |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for PD 168568 dihydrochloride
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| water | 21.12 | 50 | |
| DMSO | 42.24 | 100 |
Preparing Stock Solutions for PD 168568 dihydrochloride
The following data is based on the product molecular weight 422.39. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.37 mL | 11.84 mL | 23.67 mL |
| 5 mM | 0.47 mL | 2.37 mL | 4.73 mL |
| 10 mM | 0.24 mL | 1.18 mL | 2.37 mL |
| 50 mM | 0.05 mL | 0.24 mL | 0.47 mL |
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Product Datasheets for PD 168568 dihydrochloride
References for PD 168568 dihydrochloride
References are publications that support the biological activity of the product.
Belliotti et al (1998) Isoindolinone enantiomers having affinity for the DA D4 receptor. Bioorg.Med.Chem.Lett. 8 1499 PMID: 9873377
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Keywords: PD 168568 dihydrochloride, PD 168568 dihydrochloride supplier, Potent, selective, D4, antagonists, Dopamine, Receptors, dopaminergic, PD168568, dihydrochloride, 3529, Tocris Bioscience
1 Citation for PD 168568 dihydrochloride
Citations are publications that use Tocris products. Selected citations for PD 168568 dihydrochloride include:
Ward et al (2017) Intravitreally-administered DA D2-like (and D4), but not D1-like, receptor agonists reduce form-deprivation myopia in tree shrews. Vis Neurosci 34 E003 PMID: 28304244
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Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
Dopamine Receptors Scientific Review
Written by Phillip Strange and revised by Kim Neve in 2013, this review summarizes the history of the dopamine receptors and provides an overview of individual receptor subtype properties, their distribution and identifies ligands which act at each receptor subtype. Compounds available from Tocris are listed.
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