Home / Pharmacology / Enzymes / Hydrolases / Poly(ADP-ribose) Glycohydrolase / Poly(ADP-ribose) Glycohydrolase Inhibitors / PDD 00017272

PDD 00017272

Cat. No. 7006 1 Citation Submit a Review Datasheet / COA / SDS
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Description: Potent PARG inhibitor
Chemical Name: 1-[(2,4-Dimethyl-5-thiazolyl)methyl]-1,2,3,4-tetrahydro-N-(1-methylcyclopropyl)-3-[(2-methyl-5-thiazolyl)methyl]-2,4-dioxo-6-quinazolinesulfonamide
Purity: ≥98% (HPLC)
Datasheet
Citations (1)
Reviews
Literature (1)
Biological Activity Technical Data Solubility Calculators Datasheets References

Biological Activity for PDD 00017272

PDD 00017272 is a potent poly (ADP ribose) glycohydrolase (PARG) inhibitor (IC50 values are 4.8 nM in biochemical assay and 9.2 nM in cell based assay).

Licensing Information

Sold under license from Cancer Research Technology Ltd (Ximbio).

Technical Data for PDD 00017272

M. Wt 531.66
Formula C23H25N5O4S3
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 1945950-20-8
PubChem ID 134169694
InChI Key QOEXRJYTAZZRPL-UHFFFAOYSA-N
Smiles CC1=NC=C(S1)CN2C(N(C3=CC=C(S(=O)(NC4(CC4)C)=O)C=C3C2=O)CC5=C(N=C(S5)C)C)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for PDD 00017272

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 10.63 20 with gentle warming

Preparing Stock Solutions for PDD 00017272

The following data is based on the product molecular weight 531.66. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.2 mM 9.4 mL 47.02 mL 94.05 mL
1 mM 1.88 mL 9.4 mL 18.81 mL
2 mM 0.94 mL 4.7 mL 9.4 mL
10 mM 0.19 mL 0.94 mL 1.88 mL

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References for PDD 00017272

References are publications that support the biological activity of the product.

Waszkowycz et al (2018) Cell-active small molecule inhibitors of the DNA-damage repair enzyme poly(ADP-ribose) glycohydrolase (PARG): discovery and optimization of orally bioavailable quinazolinedione sulfonamides. J.Med.Chem. 61 10767 PMID: 30403352

If you know of a relevant reference for PDD 00017272, please let us know.

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Keywords: PDD 00017272, PDD 00017272 supplier, PDD00017272, PARG, inhibitors, poly, ADP, ribose, glycohydrolase, inhibits, PDDX-004, potent, Poly(ADP)-ribose, Glycohydrolase, 7006, Tocris Bioscience

1 Citation for PDD 00017272

Citations are publications that use Tocris products. Selected citations for PDD 00017272 include:

Petropoulos et al (2024) Transcription-replication conflicts underlie sensitivity to PARP inhibitors. Nature 628 433 PMID: 38509368

Do you know of a great paper that uses PDD 00017272 from Tocris? Please let us know.

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Literature in this Area

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Epigenetics in Cancer Poster

Epigenetics in Cancer Poster

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