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Submit ReviewPEAQX tetrasodium salt
Description: Potent and GluN2A-selective NMDA antagonist
Chemical Name: [[[(1S)-1-(4-Bromophenyl)ethyl]amino](1,2,3,4-tetrahydro-2,3-dioxo-5-quinoxalinyl)methyl] phosphonic acid tetrasodium salt
Purity: ≥98% (HPLC)
Biological Activity for PEAQX tetrasodium salt
PEAQX tetrasodium salt is a potent NMDA receptor antagonist (IC50 = 8 nM). Exhibits >100-fold selectivity for hGluN2A (formally hNR2A) containing receptors over hGluN2B (hNR2B). Anticonvulsant in vivo.
Please refer to IUPHAR Guide to Pharmacology for the most recent naming conventions.
Technical Data for PEAQX tetrasodium salt
| M. Wt | 542.14 |
| Formula | C17H13BrN3Na4O5P |
| Storage | Store at -20°C |
| Purity | ≥98% (HPLC) |
| PubChem ID | 76900415 |
| InChI Key | QBVOZIDKUFSQIL-LPOFVUTESA-J |
| Smiles | C[C@@H](C3=CC=C(Br)C=C3)NC(P([O-])([O-])=O)C1=C2C(N=C([O-])C([O-])=N2)=CC=C1.[Na+].[Na+].[Na+].[Na+] |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for PEAQX tetrasodium salt
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| water | 5.42 | 10 with gentle warming |
Preparing Stock Solutions for PEAQX tetrasodium salt
The following data is based on the product molecular weight 542.14. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 18.45 mL | 92.23 mL | 184.45 mL |
| 0.5 mM | 3.69 mL | 18.45 mL | 36.89 mL |
| 1 mM | 1.84 mL | 9.22 mL | 18.45 mL |
| 5 mM | 0.37 mL | 1.84 mL | 3.69 mL |
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Product Datasheets for PEAQX tetrasodium salt
References for PEAQX tetrasodium salt
References are publications that support the biological activity of the product.
Auberson et al (2002) 5-Phosphonomethylquinoxalinediones as competitive NMDA receptor antagonists with a preference for the human 1A/2A, rather than 1A/2B receptor composition. Bioorg.Med.Chem.Lett. 12 1099 PMID: 11909726
If you know of a relevant reference for PEAQX tetrasodium salt, please let us know.
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Keywords: PEAQX tetrasodium salt, PEAQX tetrasodium salt supplier, NVP-AAM, 077, anticonvulsants, potent, selective, NMDA, subtype, antagonists, antagonism, 459836-30-7, 2102348-87-6, Receptors, 5018, Tocris Bioscience
2 Citations for PEAQX tetrasodium salt
Citations are publications that use Tocris products. Selected citations for PEAQX tetrasodium salt include:
Pavel et al (2021) Anticonvulsant Action of GluN2A-Preferring Antagonist PEAQX in Developing Rats. Pharmaceutics 13 PMID: 33808912
Eckart D et al (2022) Ca2+ signaling in postsynaptic neurons: Neuroplastin-65 regulates the interplay between plasma membrane Ca2+ ATPases and ionotropic glutamate receptors. Cell Calcium 106 102623 PMID: 35853264
Do you know of a great paper that uses PEAQX tetrasodium salt from Tocris? Please let us know.
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