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Submit ReviewPentobarbital sodium salt
Description: Enhances GABAergic activity
Chemical Name: 5-Ethyl-5-(1-methylbutyl)-2,4,6(1H,3H,5H)-pyrimidinetrione sodium salt
Biological Activity for Pentobarbital sodium salt
Pentobarbital sodium salt enhances GABAergic activity. Pentobarbital is a short-acting barbiturate.
Technical Data for Pentobarbital sodium salt
| M. Wt | 248.25 |
| Formula | C11H17N2NaO3 |
| Storage | Store at RT |
| CAS Number | 57-33-0 |
| PubChem ID | 14075609 |
| InChI Key | QGMRQYFBGABWDR-UHFFFAOYSA-M |
| Smiles | [Na+].CCCC(C)C1(CC)C(=O)NC([O-])=NC1=O |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for Pentobarbital sodium salt
Certificate of Analysis is currently unavailable on-line.
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References for Pentobarbital sodium salt
References are publications that support the biological activity of the product.
Steinbach and Akk (2001) Modulation of GABAA receptor channel gating by pentobar. J.Physiol. 537 715 PMID: 11744750
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Keywords: Pentobarbital sodium salt, Pentobarbital sodium salt supplier, Pentobarbital, barbiturates, hypnotics, anticonvulsants, GABAergic, GABA, Miscellaneous, GABAB, Receptors, 4579, Tocris Bioscience
6 Citations for Pentobarbital sodium salt
Citations are publications that use Tocris products. Selected citations for Pentobarbital sodium salt include:
Xueyu et al (2023) Upregulation of miR-144-3p alleviates Doxorubicin-induced heart failure and cardiomyocytes apoptosis via SOCS2/PI3K/AKT axis. Chem Biol Drug Des 101 24-39 PMID: 35730258
Jost B et al (2023) Intravitreal Short-Hairpin RNA Attenuated Adeno-Associated Virus-Induced Knockdown of Amphiregulin and Axial Elongation in Experimental Myopia. Invest Ophthalmol Vis Sci 64 11 PMID: 37040096
Ying et al (2021) The P300/XBP1s/Herpud1 axis promotes macrophage M2 polarization and the development of choroidal neovascularization. J Cell Mol Med 25 6709-6720 PMID: 34057287
Jost B et al (2021) In vivo Imaging of Retina and Choroid in Guinea Pigs. Front Med (Lausanne) 8 730494 PMID: 34926491
Yan et al (2016) MicroRNA-34a affects chondrocyte apoptosis and proliferation by targeting the SIRT1/p53 signaling pathway during the pathogenesis of osteoarthritis. Nat Commun 38 201 PMID: 27247228
Konstantin et al (2020) Disruption of Cholinergic Circuits as an Area for Targeted Drug Treatment of Alzheimer's Disease: In Vivo Assessment of Short-Term Plasticity in Rat Brain. Pharmaceuticals (Basel) 13 PMID: 33050228
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Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
GABA Receptors Scientific Review
Written by Ian Martin, Norman Bowery and Susan Dunn, this review provides a history of the GABA receptor, as well as discussing the structure and function of the various subtypes and the clinical potential of receptor modulators; compounds available from Tocris are listed.