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Description: Peptide inhibitor of GluA2 subunit binding to PICK1
Biological Activity for pep2-EVKI
pep2-EVKI is an inhibitor peptide that selectively disrupts binding of the AMPA receptor subunit GluA2 (at the C-terminal PDZ site) to protein interacting with C kinase (PICK1). Does not affect binding of GluA2 to GRIP or ABP and does not increase AMPA current amplitude or affect long term depression (LTD).
Technical Data for pep2-EVKI
| M. Wt | 1326.51 |
| Formula | C62H95N13O19 |
| Sequence | YNVYGIEEVKI |
| Storage | Desiccate at -20°C |
| CAS Number | 1315378-67-6 |
| PubChem ID | 90479809 |
| InChI Key | KGQYILLVACJAQP-XMCCVONBSA-N |
| Smiles | [H]N[C@@H](CC1=CC=C(O)C=C1)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC1=CC=C(O)C=C1)C(=O)NCC(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H]([C@@H](C)CC)C(O)=O |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for pep2-EVKI
References for pep2-EVKI
References are publications that support the biological activity of the product.
Collingridge and Isaac (2003) Functional roles of protein interactions with AMPA and kainate receptors. Neurosci.Res. 47 3 PMID: 12941441
Daw et al (2000) PDZ proteins interacting with C-terminal GluR2/3 are involved in a PKC-dependent regulation of AMPA receptors at hippocampal synapses. Neuron 28 873 PMID: 11163273
Hanley et al (2002) Interaction of the AMPA receptor subunit GluR2/3 with PDZ domains regulates hippocampal long-term depression. Neuron 34 53 PMID: 11931741
Li et al (1999) AMPA receptor-PDZ interactions in facilitation of spinal sensory synapses. Nat.Neurosci. 2 972 PMID: 10526335
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Keywords: pep2-EVKI, pep2-EVKI supplier, Peptide, inhibitors, inhibits, GluR2, subunit, binding, PICK1, Glutamate, AMPA, Receptors, iGluR, Ionotropic, GluA2, 1599, Tocris Bioscience
2 Citations for pep2-EVKI
Citations are publications that use Tocris products. Selected citations for pep2-EVKI include:
Yao et al (2008) PKM ζ maintains late long-term potentiation by N-ethylmaleimide-sensitive factor/GluR2-dependent trafficking of postsynaptic AMPA receptors. Proc Natl Acad Sci U S A 28 7820 PMID: 18667614
Dickinson et al (2009) A novel mechanism of hippocampal LTD involving muscarinic receptor-triggered interactions between AMPARs, GRIP and liprin-alpha. Mol Brain 2 18 PMID: 19534762
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