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Submit ReviewBiological Activity for pep2-SVKE
Inactive control peptide analog of pep2-SVKI, an inhibitor peptide corresponding to last 10 amino acids of the C-terminus of the GluA2 AMPA receptor subunit.
Active Analog also available.
Technical Data for pep2-SVKE
| M. Wt | 1300.43 |
| Formula | C59H89N13O20 |
| Sequence | YNVYGIESVKE |
| Storage | Desiccate at -20°C |
| CAS Number | 1315378-76-7 |
| PubChem ID | 90479808 |
| InChI Key | AHURAWWDQDDHNP-OIKDQGPWSA-N |
| Smiles | [H]N[C@@H](CC1=CC=C(O)C=C1)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC1=CC=C(O)C=C1)C(=O)NCC(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CO)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(O)=O)C(O)=O |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for pep2-SVKE
References for pep2-SVKE
References are publications that support the biological activity of the product.
Collingridge and Isaac (2003) Functional roles of protein interactions with AMPA and kainate receptors. Neurosci.Res. 47 3 PMID: 12941441
Daw et al (2000) PDZ proteins interacting with C-terminal GluR2/3 are involved in a PKC-dependent regulation of AMPA receptors at hippocampal synapses. Neuron 28 873 PMID: 11163273
Kim et al (2001) Interaction of the AMPA receptor subunit GluR2/3 with PDZ domains regulates hippocampal long-term depression. Proc.Natl.Acad.Sci.U.S.A. 98 11725 PMID: 11573007
Li et al (1999) AMPA receptor-PDZ interactions in facilitation of spinal sensory synapses. Nat.Neurosci. 2 972 PMID: 10526335
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Keywords: pep2-SVKE, pep2-SVKE supplier, Inactive, control, peptide, 1597, Glutamate, AMPA, Receptors, iGlur, Ionotropic, 1598, Tocris Bioscience
1 Citation for pep2-SVKE
Citations are publications that use Tocris products. Selected citations for pep2-SVKE include:
Dickinson et al (2009) A novel mechanism of hippocampal LTD involving muscarinic receptor-triggered interactions between AMPARs, GRIP and liprin-alpha. Mol Brain 2 18 PMID: 19534762
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