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Description: Allosteric potentiator of AMPA receptor desensitization
Chemical Name: 2-[2,6-Difluoro-4-[[2-[(phenylsulfonyl)amino]ethyl]thio]phenoxy]acetamide
Purity: ≥99% (HPLC)
Biological Activity for PEPA
Novel allosteric potentiator of AMPA receptor desensitization. Slows the rate of onset of desensitization and potentiates steady-state equilibrium currents induced by glutamate with subunit (GluA3/4 > GluA1) and splice variant (flop > flip) selectivity. Ameliorates post-ischemic memory impairment in rats following i.v. administration.
Technical Data for PEPA
| M. Wt | 402.44 |
| Formula | C16H16F2N2O4S2 |
| Storage | Store at RT |
| Purity | ≥99% (HPLC) |
| CAS Number | 141286-78-4 |
| PubChem ID | 6603828 |
| InChI Key | GTACSIONMHMRPD-UHFFFAOYSA-N |
| Smiles | FC1=CC(SCCNS(C2=CC=CC=C2)(=O)=O)=CC(F)=C1OCC(N)=O |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for PEPA
References for PEPA
References are publications that support the biological activity of the product.
Sekiguchi et al (1997) A novel allosteric potentiator of AMPA receptors: 4-[2-(phenylsulfonylamino)ethylthio]-2,6-difluoro-phenoxyacetamide. J.Neurosci. 17 5760 PMID: 9221774
Sekiguchi et al (2002) A desensitization-selective potentiator of AMPA-type glutamate receptors. Br.J.Pharmacol. 136 1033 PMID: 12145103
Sekiguchi et al (2001) The AMPA receptor allosteric potentiator PEPA ameliorates post-ischemic memory impairment. Neuroreport 12 2974
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Keywords: PEPA, PEPA supplier, Allosteric, potentiator, AMPA, receptor, desensitization, desensitisation, Glutamate, Receptors, iGluR, Ionotropic, 2929, Tocris Bioscience
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