Submit a Review & Earn an Amazon Gift Card
You can now submit reviews for your favorite Tocris products. Your review will help other researchers decide on the best products for their research. Why not submit a review today?!
Submit ReviewPF 06281355
Description: Selective myeloperoxidase (MPO) inhibitor
Chemical Name: 6-(2,5-Dimethoxyphenyl)-3,4-dihydro-4-oxo-2-thioxo-1(2H)-pyrimidineacetamide
Purity: ≥98% (HPLC)
Biological Activity for PF 06281355
PF 06281355 is a selective myeloperoxidase (MPO) inhibitor (IC50 = 1.5 μM in LPS-stimulated human whole blood). Selective for MPO over a panel of 50 receptors, enzymes, ion channels and transporters, including thyroid peroxidase. Inhibits MPO activity in peritoneal lavage and plasma in a murine peritonitis model. Also reduces lung edema in a murine pulmonary immune complex vasculitis model. Orally bioavailable.
Licensing Information
Sold for research purposes under agreement from Pfizer Inc
Technical Data for PF 06281355
| M. Wt | 321.35 |
| Formula | C14H15N3O4S |
| Storage | Store at RT |
| Purity | ≥98% (HPLC) |
| CAS Number | 1435467-38-1 |
| PubChem ID | 71568997 |
| InChI Key | LJBUZOGABRDGBR-UHFFFAOYSA-N |
| Smiles | COC1=CC(C2=CC(NC(N2CC(N)=O)=S)=O)=C(C=C1)OC |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for PF 06281355
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 6.43 | 20 with gentle warming |
Preparing Stock Solutions for PF 06281355
The following data is based on the product molecular weight 321.35. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.2 mM | 15.56 mL | 77.8 mL | 155.59 mL |
| 1 mM | 3.11 mL | 15.56 mL | 31.12 mL |
| 2 mM | 1.56 mL | 7.78 mL | 15.56 mL |
| 10 mM | 0.31 mL | 1.56 mL | 3.11 mL |
Molarity Calculator
Molarity Calculator
Calculate the mass, volume, or concentration required for a solution.
Reconstitution Calculator
Reconstitution Calculator
Dilution Calculator
Dilution Calculator
Calculate the dilution required to prepare a stock solution.
Product Datasheets for PF 06281355
References for PF 06281355
References are publications that support the biological activity of the product.
Zheng et al (2015) PF-1355, a mechanism-based myeloperoxidase inhibitor, prevents immune complex vasculitis and anti-glomerular basement membrane glomerulonephritis. J.Pharmacol.Exp.Ther. 353 288 PMID: 25698787
Ruggeri et al (2015) Discovery of 2-(6-(5-chloro-2-methoxyphenyl)-4-oxo-2-thioxo-3,4-dihydropyrimidin-1(2H)-yl)acetamide (PF-06282999): A highly selective mechanism-based myeloperoxidase inhibitor for the treatment of cardiovascular diseases. J.Med.Chem. 58 8513 PMID: 26509551
If you know of a relevant reference for PF 06281355, please let us know.
View Related Products by Target
View Related Products by Product Action
Keywords: PF 06281355, PF 06281355 supplier, PF06281355, myeloperoxidase, inhibitors, inhibits, selective, orally, bioavailable, vasculitis, Other, Oxygenases/Oxidases, 6004, Tocris Bioscience
Citations for PF 06281355
Citations are publications that use Tocris products.
Currently there are no citations for PF 06281355. Do you know of a great paper that uses PF 06281355 from Tocris? Please let us know.
Reviews for PF 06281355
There are currently no reviews for this product. Be the first to review PF 06281355 and earn rewards!
Have you used PF 06281355?
Submit a review and receive an Amazon gift card.
$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image
$25/€18/£15/$25CAN/¥75 Yuan/¥2500 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image