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Submit ReviewPF 4981517
Description: Selective CYP3A4 inhibitor
Chemical Name: (1-Methyl-3-[1-methyl-5-(4-methylphenyl)-1H-pyrazol-4-yl]-4-[(3S)-3-piperidin-1-ylpyrrolidin-1-yl]-1H-pyrazolo[3,4-d]pyrimidine)
Purity: ≥98% (HPLC)
Biological Activity for PF 4981517
PF 4981517 is a potent and selective inhibitor of CYP3A4 (IC50 values are 0.03, 17 and 70 μM for CYP3A4, CYP3A5 and CYP3A7 respectively).
Licensing Information
Sold for research purposes under agreement from Pfizer Inc.
Technical Data for PF 4981517
| M. Wt | 456.59 |
| Formula | C26H32N8 |
| Storage | Store at +4°C |
| Purity | ≥98% (HPLC) |
| CAS Number | 1390637-82-7 |
| PubChem ID | 71315139 |
| InChI Key | WDWIMDKOXZZYHH-FQEVSTJZSA-N |
| Smiles | CN1N=C(C5=C(C6=CC=C(C)C=C6)N(C)N=C5)C2=C1N=CN=C2N3C[C@@H](N4CCCCC4)CC3 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for PF 4981517
References for PF 4981517
References are publications that support the biological activity of the product.
Walsky et al (2012) Selective mechanism-based inactivation of cytochrome P4503A4 by cyp3cide (PF-04981517) and its utility as an in vitro tool for delineating the relative roles of cytochrome P4503A4 versus P4503A5 in the metabolism of drugs. Am.Soc.Pharmacol.Exp.Ther. Epub ahead of print
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Keywords: PF 4981517, PF 4981517 supplier, pfizer, PF4981517, selective, inhibitors, inhibits, cyp3a4, cytochrome, p4503A4, cyp3cide, Cytochrome, P450, 4252, Tocris Bioscience
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