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Submit ReviewPF 9184
Description: Potent microsomal prostaglandin E synthase 1 (mPGES-1) inhibitor
Chemical Name: N-[3',4'-Dichloro(1,1'-biphenyl)-yl]-4-hydroxy-2H-1,2-benzothiazine-3-carboxamide 1,1-dioxide
Purity: ≥98% (HPLC)
Biological Activity for PF 9184
PF 9184 is a potent microsomal prostaglandin E synthase 1 (mPGES-1) inhibitor (IC50 values are 16.5 and 1080 nM for human and rat mPGES-1, respectively). Exhibits >6500-fold selectivity for mPGES-1 over COX-1 and COX-2. Inhibits IL-1β-induced PGE2 synthesis in vitro.
Licensing Information
Sold for research purposes under agreement from Pfizer Inc.
Technical Data for PF 9184
| M. Wt | 461.32 |
| Formula | C21H14Cl2N2O4S |
| Storage | Store at -20°C |
| Purity | ≥98% (HPLC) |
| CAS Number | 1221971-47-6 |
| PubChem ID | 54728414 |
| InChI Key | VGACSWBJQLLJFB-UHFFFAOYSA-N |
| Smiles | OC2=C(C(NC3=CC=C(C4=CC=C(Cl)C(Cl)=C4)C=C3)=O)NS(C1=CC=CC=C12)(=O)=O |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for PF 9184
References for PF 9184
References are publications that support the biological activity of the product.
Mbalaviele et al (2010) Distinction of microsomal prostaglandin E synthase-1 (mPGES-1) inhibition from cyclooxygenase-2 inhibition in cells using a novel, selective mPGES-1 inhibitor. Biochem.Pharmacol. 79 1445 PMID: 20067770
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Keywords: PF 9184, PF 9184 supplier, PF9184, potent, microsomal, prostaglandins-E, synthases, mPGES-1, inhibitors, inhibits, Other, Synthases/Synthetases, 5917, Tocris Bioscience
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