Submit a Review & Earn an Amazon Gift Card
You can now submit reviews for your favorite Tocris products. Your review will help other researchers decide on the best products for their research. Why not submit a review today?!
Submit ReviewPF 998425
Description: Non-steroidal androgen receptor antagonist
Chemical Name: 4-((1R,2R)-2-Hydroxycyclohexyl)-2(trifluoromethyl)benzonitrile
Purity: ≥98% (HPLC)
Biological Activity for PF 998425
Selective non-steroidal androgen receptor (AR) antagonist (IC50 values are 26 nM and 90 nM in AR binding assays and cellular assays respectively). Displays low affinity for progesterone receptor (IC50 > 10 μM). Active in vivo.
Licensing Information
Sold for research purposes under agreement from Pfizer Inc.
Technical Data for PF 998425
| M. Wt | 269.26 |
| Formula | C14H14F3NO |
| Storage | Store at +4°C |
| Purity | ≥98% (HPLC) |
| CAS Number | 1076225-27-8 |
| PubChem ID | 25093231 |
| InChI Key | MENRRRXHFQYXDW-DGCLKSJQSA-N |
| Smiles | O[C@H](CCCC2)[C@H]2[C@]1=CC(C(F)(F)F)=C(C#N)C=C1 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for PF 998425
References for PF 998425
References are publications that support the biological activity of the product.
Li et al (2008) Rational design and synthesis of 4-((1R,2R)-2-hydroxycyclohexyl)-2(trifluoromethyl)benzonitrile (PF-998425), a novel, nonsteroidal androgen receptor antagonist devoid of phototoxicity for dermatological indications. J.Med.Chem. 51 7010 PMID: 18921992
View Related Products by Target
View Related Products by Product Action
Keywords: PF 998425, PF 998425 supplier, selective, nonsteroidal, androgen, receptors, antagonists, PF998425, Pfizer, Androgen, Receptor, 3923, Tocris Bioscience
Citations for PF 998425
Citations are publications that use Tocris products.
Currently there are no citations for PF 998425.
Reviews for PF 998425
There are currently no reviews for this product. Be the first to review PF 998425 and earn rewards!
Have you used PF 998425?
Submit a review and receive an Amazon gift card.
$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image
$25/€18/£15/$25CAN/¥75 Yuan/¥2500 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image