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Submit Review[(pF)Phe4]Nociceptin(1-13)NH2
Description: Potent, selective nociceptin receptor agonist
Biological Activity for [(pF)Phe4]Nociceptin(1-13)NH2
[(pF)Phe4]Nociceptin(1-13)NH2 is a highly potent and selective nociceptin/orphanin FQ receptor (OP4) agonist peptide (pKi = 10.68; pEC50 = 9.80). Displays > 8000-fold selectivity over δ, κ, and μ opioid receptors and has relatively long lasting pronociceptive, hypotensive, negative inotropic and feeding stimulation effects in vivo.
Technical Data for [(pF)Phe4]Nociceptin(1-13)NH2
| M. Wt | 1399.6 |
| Formula | C61H99FN22O15 |
| Sequence |
FGGFTGARKSARK (Modifications: Phe-4 = p-fluoro-Phe, Lys-14 = C-terminal amide) |
| Storage | Desiccate at -20°C |
| CAS Number | 380620-88-2 |
| PubChem ID | 10260917 |
| InChI Key | OGKNRWXOEHEYOV-QHYQKCGXSA-N |
| Smiles | [H]N[C@@H](CC1=CC=CC=C1)C(=O)NCC(=O)NCC(=O)N[C@@H](CC1=CC=C(F)C=C1)C(=O)N[C@@H]([C@@H](C)O)C(=O)NCC(=O)N[C@@H](C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CO)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCCN)C(N)=O |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for [(pF)Phe4]Nociceptin(1-13)NH2
References for [(pF)Phe4]Nociceptin(1-13)NH2
References are publications that support the biological activity of the product.
Bigoni et al (2002) Pharmacological characterisation of [(pX)Phe4]nociceptin(1-13)amide analogues. 1. In vitro studies. Naunyn Schmiedebergs Arch.Pharmacol. 365 442 PMID: 12070757
Guerrini et al (2001) Structure-activity studies of the Phe4 residue of nociceptin(1-13)-NH2: Identification of highly potent agonists of the nociceptin/orphanin FQ receptor. J.Med.Chem. 44 3956 PMID: 11689082
Rizzi et al (2002) Pharmacological characterisation of [(pX)Phe4]nociceptin(1-13)amide analogues. 2. In vivo studies. Naunyn Schmiedebergs Arch.Pharmacol. 365 450 PMID: 12070758
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Keywords: [(pF)Phe4]Nociceptin(1-13)NH2, [(pF)Phe4]Nociceptin(1-13)NH2 supplier, Potent, selective, nociceptin, receptor, agonists, Receptors, ORL1, OP4, NOP, Opioids, 1566, Tocris Bioscience
Citations for [(pF)Phe4]Nociceptin(1-13)NH2
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Currently there are no citations for [(pF)Phe4]Nociceptin(1-13)NH2.
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Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
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Peptides Involved in Appetite Modulation Scientific Review
Written by Sonia Tucci, Lynsay Kobelis and Tim Kirkham, this review provides a synopsis of the increasing number of peptides that have been implicated in appetite regulation and energy homeostasis; putative roles of the major peptides are outlined and compounds available from Tocris are listed.