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Submit ReviewPhencyclidine hydrochloride
Description: Non-competitive NMDA antagonist
Alternative Names: PCP
Chemical Name: 1-(1-Phenylcyclohexyl)piperidine hydrochloride
Purity: ≥99% (HPLC)
Biological Activity for Phencyclidine hydrochloride
Phencyclidine hydrochloride is a non-competitive NMDA receptor antagonist and sigma receptor agonist. Psychostimulant; induces rotational behavior, head-weaving and cognitive dysfunction in rats.
Technical Data for Phencyclidine hydrochloride
| M. Wt | 279.85 |
| Formula | C17H25N.HCl |
| Storage | Store at RT |
| Purity | ≥99% (HPLC) |
| CAS Number | 956-90-1 |
| PubChem ID | 13727 |
| InChI Key | BUAJNGPDPGKBGV-UHFFFAOYSA-N |
| Smiles | N2(CCCCC2)C1(C3=CC=CC=C3)CCCCC1.Cl |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for Phencyclidine hydrochloride
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| water | 11.19 | 40 |
Preparing Stock Solutions for Phencyclidine hydrochloride
The following data is based on the product molecular weight 279.85. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.4 mM | 8.93 mL | 44.67 mL | 89.33 mL |
| 2 mM | 1.79 mL | 8.93 mL | 17.87 mL |
| 4 mM | 0.89 mL | 4.47 mL | 8.93 mL |
| 20 mM | 0.18 mL | 0.89 mL | 1.79 mL |
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Product Datasheets for Phencyclidine hydrochloride
References for Phencyclidine hydrochloride
References are publications that support the biological activity of the product.
Linders et al (1993) Synthesis and binding properties of MK-801 isothiocyanates; (+)-3-isothiocyanato-5-methyl-10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5,10-imine hydrochloride: a new potent and selective electrophilic affinity ligand for the NMDA receptor-c J.Med.Chem. 36 2499 PMID: 8355251
Jin et al (1997) The involvement of σ receptors in the choice reaction performance deficits induced by phencyclidine. Eur.J.Pharmacol. 319 147 PMID: 9042584
Sharp (1997) Phencyclidine (PCP) acts at σ sites to induce c-fos gene expression. Brain Res. 758 51 PMID: 9203533
If you know of a relevant reference for Phencyclidine hydrochloride, please let us know.
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Keywords: Phencyclidine hydrochloride, Phencyclidine hydrochloride supplier, σ, sigma, receptor, agonists, Non-competitive, NMDA, antagonists, General, Receptors, Glutamate, N-Methyl-D-Aspartate, iGluR, Ionotropic, PCP, Sigma-Related, 2557, Tocris Bioscience
Citations for Phencyclidine hydrochloride
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