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Submit ReviewPhenserine
Description: Cholinesterase inhibitor
Chemical Name: (3aS,8aR)-1,2,3,3a,8,8a-Hexahydro-1,3a,8-trimethylpyrrolo[2,3-b]indol-5-ol 5-(N-phenylcarbamate)
Purity: ≥98% (HPLC)
Biological Activity for Phenserine
Physostigmine analog that inhibits acetylcholinesterase. Inhibits production of amyloid precursor protein (APP) and Aβ. Improves morris water maze performance of scopolamine-treated rats.
Technical Data for Phenserine
| M. Wt | 337.42 |
| Formula | C20H23N3O2 |
| Storage | Store at +4°C |
| Purity | ≥98% (HPLC) |
| CAS Number | 101246-66-6 |
| PubChem ID | 192706 |
| InChI Key | PBHFNBQPZCRWQP-QUCCMNQESA-N |
| Smiles | O=C(OC2=CC=C(N(C)[C@]4([H])[C@](C)3CCN4C)C3=C2)NC1=CC=CC=C1 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for Phenserine
References for Phenserine
References are publications that support the biological activity of the product.
Janas et al (2005) The cholinesterase inhibitor, phenserine, improves morris water maze performance of scopolamine-treated rats. Life Sci. 76 1073 PMID: 15620572
Utsuki et al (2006) Identification of novel small molecule inhibitors of amyloid precursor protein synthesis as a route to lower Alzheimer's disease amyloid-β peptide. J.Pharmacol.Exp.Ther. 318 855 PMID: 16690718
Klein (2007) Phenserine. Expert Opin.Investig.Drugs 16 1087 PMID: 17594192
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Keywords: Phenserine, Phenserine supplier, Cholinesterase, inhibitors, inhibits, AChE, Acetylcholinesterase, Esterases, Acetylcholine, Nicotinic, Receptors, nAChR, Muscarinic, Cholinesterases, Non-selective, Muscarinics, 2967, Tocris Bioscience
1 Citation for Phenserine
Citations are publications that use Tocris products. Selected citations for Phenserine include:
Elgueta et al (2015) Acetylcholine induces GABA release onto rod bipolar cells through heteromeric nicotinic receptors expressed in A17 amacrine cells. Sci Rep 9 6 PMID: 25709566
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Alzheimer's Disease Poster
Alzheimer's disease (AD) is a debilitating and progressive neurodegenerative disease and the most common cause of dementia, affecting approximately 30% of individuals aged over 85 years. This poster summarizes the cellular and molecular mechanisms of AD.