Home / Pharmacology / GPCRs / 7-TM Receptors / Adrenergic Receptors / Non-selective Adrenergic α Receptors / Non-selective Adrenergic α Receptor Antagonists / Phentolamine Mesylate

Phentolamine Mesylate

Cat. No. 6431 2 Citations Submit a Review Datasheet / COA / SDS
Pricing Availability   Qty
Description: Adrenergic α receptor antagonist; antihypertensive
Chemical Name: 3-[[(4,5-Dihydro-1H-imidazol-2-yl)methyl](4-methylphenyl)amino]phenol methanesulfonate
Purity: ≥98% (HPLC)
Datasheet
Citations (2)
Reviews
Literature (1)
Biological Activity Technical Data Solubility Calculators Datasheets References

Biological Activity for Phentolamine Mesylate

Phentolamine Mesylate is a non-selective adrenergic α receptor antagonist (pKB = 8.07). Intravenous injection causes hypotension and tachycardia in rats. Intraperitoneal injection in mice increases plasma FGF21 levels.

Compound Libraries for Phentolamine Mesylate

Phentolamine Mesylate is also offered as part of the Tocriscreen 2.0 Max and Tocriscreen FDA-Approved Drugs. Find out more about compound libraries available from Tocris.

Technical Data for Phentolamine Mesylate

M. Wt 377.46
Formula C17H19N3O.CH4O3S
Storage Store at +4°C
Purity ≥98% (HPLC)
CAS Number 65-28-1
PubChem ID 91430
InChI Key OGIYDFVHFQEFKQ-UHFFFAOYSA-N
Smiles CS(O)(=O)=O.CC1=CC=C(N(C2=CC(O)=CC=C2)CC3=NCCN3)C=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for Phentolamine Mesylate

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
water 37.75 100
DMSO 37.75 100

Preparing Stock Solutions for Phentolamine Mesylate

The following data is based on the product molecular weight 377.46. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.65 mL 13.25 mL 26.49 mL
5 mM 0.53 mL 2.65 mL 5.3 mL
10 mM 0.26 mL 1.32 mL 2.65 mL
50 mM 0.05 mL 0.26 mL 0.53 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.
=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Dilution Calculator

Calculate the dilution required to prepare a stock solution.
x
=
x

Product Datasheets for Phentolamine Mesylate

Certificate of Analysis / Product Datasheet
Safety Datasheet

References for Phentolamine Mesylate

References are publications that support the biological activity of the product.

Liu & Coupar (1996) Evidence for functional alpha 2D-adrenoceptors in the rat intestine. Br.J.Pharmacol. 117 787 PMID: 8851491

Fioretti et al (2017) Renal and femoral venous blood flows are regulated by different mechanisms dependent on α-adrenergic receptor subtypes and nitric oxide in anesthetized rats. Vascul.Pharmacol. 99 53 PMID: 28986330

Nonogaki & Kaji (2017) α1-adrenergic receptor downregulated hepatic FGF21 production and circulating FGF21 levels in mice. Neurosci.Lett. 18 35 PMID: 27939978

If you know of a relevant reference for Phentolamine Mesylate, please let us know.

View Related Products by Target

View Related Products by Product Action

View all Non-selective Adrenergic α Receptor Antagonists

Keywords: Phentolamine Mesylate, Phentolamine Mesylate supplier, Phentolamine, non, selective, alpha, adrenergic, receptor, antagonists, antagonism, antihypertensive, adrenoceptor, Non-selective, Adrenergic, Alpha, Receptors, 6431, Tocris Bioscience

2 Citations for Phentolamine Mesylate

Citations are publications that use Tocris products. Selected citations for Phentolamine Mesylate include:

Kira E et al (2022) Dopamine activates astrocytes in prefrontal cortex via α1-adrenergic receptors. Cell Rep 40 111426 PMID: 36170823

David R et al (2021) Propranolol Sensitizes Vascular Sarcoma Cells to Doxorubicin by Altering Lysosomal Drug Sequestration and Drug Efflux. Front Oncol 10 614288 PMID: 33598432

Do you know of a great paper that uses Phentolamine Mesylate from Tocris? Please let us know.

Reviews for Phentolamine Mesylate

There are currently no reviews for this product. Be the first to review Phentolamine Mesylate and earn rewards!

Have you used Phentolamine Mesylate?

Submit a review and receive an Amazon gift card.

$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image

$25/€18/£15/$25CAN/¥75 Yuan/¥2500 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review

Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.

Depression Poster

Depression Poster

Major depressive disorder is characterized by depressed mood and a loss of interest and/or pleasure. Updated in 2015 this poster highlights presynaptic and postsynaptic targets for the potential treatment of major depressive disorder, as well as outlining the pharmacology of currently approved antidepressant drugs.