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Submit ReviewPhilanthotoxin 74
Description: GluA1 and GluA3 selective AMPA antagonist
Alternative Names: PhTx-74
Chemical Name: (S)-N-[7-[(4-Aminobutyl)amino]heptyl]-4-hydroxy-α-[(1-oxobutyl)amino]benzenepropanamide dihydrochloride
Purity: ≥98% (HPLC)
Biological Activity for Philanthotoxin 74
Philanthotoxin 74 is an AMPA receptor antagonist. Non-selective homomeric GluA3 and GluA1 receptor antagonist (IC50 values are 263 and 296 nM respectively). Inhibits homomeric GluA3 and GluA1 with a 100-fold greater potency than heteromeric GluA1/2 and GluA2/3 receptors.
Technical Data for Philanthotoxin 74
| M. Wt | 507.54 |
| Formula | C24H42N4O3.2HCl |
| Storage | Desiccate at RT |
| Purity | ≥98% (HPLC) |
| CAS Number | 1227301-51-0 |
| PubChem ID | 46213501 |
| InChI Key | HWTJQQMIKVJWLH-IKXQUJFKSA-N |
| Smiles | OC1=CC=C(C[C@H](NC(CCC)=O)C(NCCCCCCCNCCCCN)=O)C=C1.Cl.Cl |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for Philanthotoxin 74
References for Philanthotoxin 74
References are publications that support the biological activity of the product.
Nilsen and England (2007) A subtype-selective, use-dependent inhibitor of native AMPA receptors. J.Am.Chem.Soc. 129 4902 PMID: 17391037
Poulsen et al (2013) Evaluation of PhTX-74 as subtype-selective inhibitor of GluA2-containing AMPA receptors. Mol.Pharmacol. 85 261 PMID: 24220009
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Keywords: Philanthotoxin 74, Philanthotoxin 74 supplier, GluR1/2, selective, AMPA, antagonists, Glutamate, Receptors, iGluR, Ionotropic, Philanthotoxin74, PhTx74, homomeric, GluR3, GluR1, GluR2/3, GluA1, GluA2, GluA3, PhTx-74, 2770, Tocris Bioscience
2 Citations for Philanthotoxin 74
Citations are publications that use Tocris products. Selected citations for Philanthotoxin 74 include:
Kim and Ziff (2014) Calcineurin mediates synaptic scaling via synaptic trafficking of Ca2+-permeable AMPA receptors. PLoS Biol 12 e1001900 PMID: 24983627
Zhao et al (2018) Soluble Aβ Oligomers Impair Dipolar Heterodendritic Plasticity by Activation of mGluR in the Hippocampal CA1 Region. iScience 6 138 PMID: 30240608
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