Phortress

Cat. No. 4995 Submit a Review Datasheet / COA / SDS

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Description: Prodrug of the antitumor agent 5F 203

Chemical Name: (2S)-2,6-Diamino-N-[4-(5-fluoro-2-benzothiazolyl)-2-methylphenyl]hexanamide dihydrochloride

Purity: ≥98% (HPLC)

Datasheet

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Biological Activity Technical Data Solubility Calculators Datasheets References

Biological Activity for Phortress

Phortress is a prodrug of the antitumor agent 5F 203, which acts via binding to aryl hydrocarbon receptors. Induces expression of CYP1A1 and generates adducts in the DNA of sensitive MCF7 and IGROV-1 cells.

Technical Data for Phortress

M. Wt	459.41
Formula	C₂₀H₂₃FN₄OS.2HCl
Storage	Store at -20°C
Purity	≥98% (HPLC)
CAS Number	328087-38-3
PubChem ID	9804228
InChI Key	QZSMNTOCJVVFEU-CKUXDGONSA-N
Smiles	FC1=CC=C2C(N=C(C3=CC=C(NC([C@H](CCCCN)N)=O)C(C)=C3)S2)=C1.Cl.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for Phortress

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO		100

Preparing Stock Solutions for Phortress

The following data is based on the product molecular weight 459.41. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.18 mL	10.88 mL	21.77 mL
5 mM	0.44 mL	2.18 mL	4.35 mL
10 mM	0.22 mL	1.09 mL	2.18 mL
50 mM	0.04 mL	0.22 mL	0.44 mL

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Product Datasheets for Phortress

Certificate of Analysis / Product Datasheet

Safety Datasheet

References for Phortress

References are publications that support the biological activity of the product.

Leong et al (2003) Antitumour 2-(4-aminophenyl)benzothiazoles generate DNA adducts in sensitive tumour cells in vitro and in vivo. Br.J.Cancer 88 470 PMID: 12569393

Leong et al (2004) In vitro, in vivo and in silico analyses of the antitumor activity of 2(-4-amino-3-methylphenyl)-5-fluorobenzothiazoles. Mol.Cancer Ther. 3 1565 PMID: 15634650

Trapani et al (2003) DNA damage and cell cycle arrest induced by 2-(4-amino-3-methylphenyl)-5-fluorobenzothiazole (5F 203, NSC 703786) is attenuated by aryl hydrocarbon receptor deficient MCF-7 cells. Br.J.Cancer 88 599 PMID: 12592376

Bradshaw and Westwell (2004) The development of the antitumour benzothiazole prodrug, phortress, as a clinical candidate. Curr.Med.Chem. 11 1241 PMID: 15078163

If you know of a relevant reference for Phortress, please let us know.

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Keywords: Phortress, Phortress supplier, antitumor, antitumour, cytotoxic, prodrug, aryl, hydrocarbon, receptors, AhRs, Aryl, Hydrocarbon, Receptors, 4995, Tocris Bioscience

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