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Submit ReviewPHP 501 trifluoroacetate
Description: Potent GABAA antagonist
Chemical Name: 4-(5-[1,1'-Biphenyl]-3-yl-1-hydroxy-1H-pyrazol-4-yl)piperidine trifluoroacetate
Purity: ≥98% (HPLC)
Biological Activity for PHP 501 trifluoroacetate
PHP 501 trifluoroacetate is a potent GABAA antagonist (Ki = 0.0028 μM at rat GABAA receptors; IC50 = 0.024 μM at human α1β2γ2 GABAA-expressing tsA201 cells). Displays no inhibitory activity at hGAT-1, hGAT-2, hGAT-3 or hBGT-1 GABA transporters.
Technical Data for PHP 501 trifluoroacetate
| M. Wt | 433.42 |
| Formula | C20H21N3O.CF3CO2H |
| Storage | Store at -20°C |
| Purity | ≥98% (HPLC) |
| CAS Number | 1781880-44-1 |
| PubChem ID | 90488945 |
| InChI Key | SULXXKLCQRXMHP-UHFFFAOYSA-N |
| Smiles | ON1N=CC(C3CCNCC3)=C1C2=CC=CC(C4=CC=CC=C4)=C2.FC(F)(C(O)=O)F |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for PHP 501 trifluoroacetate
References for PHP 501 trifluoroacetate
References are publications that support the biological activity of the product.
Møller et al (2010) Novel 4-(piperidin-4-yl)-1-hydroxypyrazoles as gamma-aminobutyric acid(A) receptor ligands: synthesis, pharmacology, and structure-activity relationships. J.Med.Chem. 53 3417 PMID: 20355712
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Keywords: PHP 501 trifluoroacetate, PHP 501 trifluoroacetate supplier, GABAA, receptors, antagonists, potent, PHP501, Receptors, 4466, Tocris Bioscience
1 Citation for PHP 501 trifluoroacetate
Citations are publications that use Tocris products. Selected citations for PHP 501 trifluoroacetate include:
León et al (2016) Direct actions of kisspeptins on GnRH neurons permit attainment of fertility but are insufficient to fully preserve gonadotropic axis activity. Sci.Rep. 6 19206 PMID: 26755241
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Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
GABA Receptors Scientific Review
Written by Ian Martin, Norman Bowery and Susan Dunn, this review provides a history of the GABA receptor, as well as discussing the structure and function of the various subtypes and the clinical potential of receptor modulators; compounds available from Tocris are listed.
Addiction Poster
The key feature of drug addiction is the inability to stop using a drug despite clear evidence of harm. This poster describes the brain circuits associated with addiction, and provides an overview of the main classes of addictive drugs and the neurotransmitter systems that they target.