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Submit ReviewPhysostigmine hemisulfate
Description: Cholinesterase inhibitor
Chemical Name: (3aS)-cis-1,2,3,3a,8,8a-Hexahydro-1,3a,8-trimethylpyrrolo[2,3-b]indol-5-ol methylcarbamate hemisulfate
Purity: ≥98% (HPLC)
Biological Activity for Physostigmine hemisulfate
Physostigmine hemisulfate is a cholinesterase inhibitor.
Technical Data for Physostigmine hemisulfate
| M. Wt | 324.39 |
| Formula | C15H21N3O2.½H2SO4 |
| Storage | Desiccate at RT |
| Purity | ≥98% (HPLC) |
| CAS Number | 64-47-1 |
| PubChem ID | 21872909 |
| InChI Key | YYBNDIVPHIWTPK-UHFFFAOYSA-N |
| Smiles | OS(O)(=O)=O.CNC(=O)OC1=CC=C2N(C)C3N(C)CCC3(C)C2=C1.CNC(=O)OC1=CC=C2N(C)C3N(C)CCC3(C)C2=C1 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for Physostigmine hemisulfate
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| water | 32.44 | 100 |
Preparing Stock Solutions for Physostigmine hemisulfate
The following data is based on the product molecular weight 324.39. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 3.08 mL | 15.41 mL | 30.83 mL |
| 5 mM | 0.62 mL | 3.08 mL | 6.17 mL |
| 10 mM | 0.31 mL | 1.54 mL | 3.08 mL |
| 50 mM | 0.06 mL | 0.31 mL | 0.62 mL |
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Product Datasheets for Physostigmine hemisulfate
References for Physostigmine hemisulfate
References are publications that support the biological activity of the product.
Millard and Broomfield (1995) Anticholinesterases: medical applications of neurochemical principles. J.Neurochem 64 1909 PMID: 7722478
Merck Index 12 7540
If you know of a relevant reference for Physostigmine hemisulfate, please let us know.
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Keywords: Physostigmine hemisulfate, Physostigmine hemisulfate supplier, Cholinesterase, inhibitors, inhibits, AChE, Acetylcholinesterase, Esterases, Acetylcholine, Nicotinic, Receptors, nAChR, Muscarinic, Non-selective, Muscarinics, Cholinesterases, 0622, Tocris Bioscience
6 Citations for Physostigmine hemisulfate
Citations are publications that use Tocris products. Selected citations for Physostigmine hemisulfate include:
Huchzermeyer et al (2013) Oxygen consumption rates during three different neuronal activity states in the hippocampal CA3 network. J Cereb Blood Flow Metab 33 263 PMID: 23168532
Lecrux et al (2017) Impact of Altered Cholinergic Tones on the Neurovascular Coupling Response to Whisker Stimulation. J Neurosci 37 1518 PMID: 28069927
Galow et al (2014) Energy substrates that fuel fast neuronal network oscillations. J Neurosci 8 398 PMID: 25538552
Parent et al (2015) Cholinergic and ghrelinergic receptors and KCNQ channels in the medial PFC regulate the expression of palatability. Proc Natl Acad Sci U S A 9 284 PMID: 26578914
Shin et al (2015) Muscarinic regulation of DA and glutamate transmission in the nucleus accumbens. Front Neurosci 112 8124 PMID: 26080439
Chiu and Castillo (2008) Input-specific plasticity at excitatory synapses mediated by endocannabinoids in the dentate gyrus. Neuropharmacology 54 68 PMID: 17706254
Do you know of a great paper that uses Physostigmine hemisulfate from Tocris? Please let us know.
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