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Submit ReviewPKUMDL WQ 2101
Description: Negative allosteric modulator of 3-phosphoglycerate dehydrogenase (PHGDH)
Chemical Name: 2,4-Dihydroxy-N'-(2-hydroxy-5-nitrobenzylidene)benzohydrazide
Purity: ≥98% (HPLC)
Biological Activity for PKUMDL WQ 2101
PKUMDL WQ 2101 is a negative allosteric modulator of phosphoglycerate dehydrogenase (PHGDH) (IC50 = 34.8 μM). Exhibits antitumor activity in vitro in breast cancer cells lines overexpressing PHGDH (EC50 values are 7.7 and 10.8 μM in MDA-MB-468 and HCC-70 cells, respectively). Inhibits growth of MDA-MB-468 xenografts in mice.
Technical Data for PKUMDL WQ 2101
| M. Wt | 317.25 |
| Formula | C14H11N3O6 |
| Storage | Store at -20°C |
| Purity | ≥98% (HPLC) |
| CAS Number | 304481-72-9 |
| PubChem ID | 6741780 |
| InChI Key | RABUUVVWWJCYEN-UHFFFAOYSA-N |
| Smiles | OC1=CC(O)=C(C(N/N=C/C2=CC([N+]([O-])=O)=CC=C2O)=O)C=C1 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for PKUMDL WQ 2101
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 31.73 | 100 |
Preparing Stock Solutions for PKUMDL WQ 2101
The following data is based on the product molecular weight 317.25. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 3.15 mL | 15.76 mL | 31.52 mL |
| 5 mM | 0.63 mL | 3.15 mL | 6.3 mL |
| 10 mM | 0.32 mL | 1.58 mL | 3.15 mL |
| 50 mM | 0.06 mL | 0.32 mL | 0.63 mL |
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Product Datasheets for PKUMDL WQ 2101
References for PKUMDL WQ 2101
References are publications that support the biological activity of the product.
Wang et al (2017) Rational design of selective allosteric inhibitors of PHGDH and serine synthesis with anti-tumor activity. Cell Chem.Biol. 24 55 PMID: 28042046
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Keywords: PKUMDL WQ 2101, PKUMDL WQ 2101 supplier, PKUMDLWQ2101, Phosphoglycerate, dehydrogenase, PHGDH, allosteric, inhibitor, serine, biosynthesis, negative, modulator, NAM, Other, Dehydrogenases, 6580, Tocris Bioscience
1 Citation for PKUMDL WQ 2101
Citations are publications that use Tocris products. Selected citations for PKUMDL WQ 2101 include:
John M et al (2022) Purine nucleotide depletion prompts cell migration by stimulating the serine synthesis pathway. Nat Commun 13 2698 PMID: 35577785
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