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Submit ReviewPKUMDL WQ 2201
Description: Negative allosteric modulator of 3-Phosphoglycerate dehydrogenase (PHGDH)
Chemical Name: 2-Chloro-4-[5-[[2-[(ethylamino)thioxomethyl]hydrazinylidene]methyl]-2-furanyl]benzoic acid
Purity: ≥98% (HPLC)
Biological Activity for PKUMDL WQ 2201
PKUMDL WQ 2201 is a negative allosteric modulator of phosphoglycerate dehydrogenase (PHGDH) (IC50 = 35.7 μM). Displays dose-dependent suppression of cell viability in a range of cancer cell lines. Inhibits tumor growth in a xenograft mouse model.
Technical Data for PKUMDL WQ 2201
| M. Wt | 351.81 |
| Formula | C15H14ClN3O3S |
| Storage | Store at -20°C |
| Purity | ≥98% (HPLC) |
| CAS Number | 592474-91-4 |
| PubChem ID | 5453153 |
| InChI Key | XPACBFAEZIPDRT-LSCVHKIXSA-N |
| Smiles | CCNC(N/N=C/C1=CC=C(C2=CC(Cl)=C(C(O)=O)C=C2)O1)=S |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for PKUMDL WQ 2201
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 35.18 | 100 |
Preparing Stock Solutions for PKUMDL WQ 2201
The following data is based on the product molecular weight 351.81. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.84 mL | 14.21 mL | 28.42 mL |
| 5 mM | 0.57 mL | 2.84 mL | 5.68 mL |
| 10 mM | 0.28 mL | 1.42 mL | 2.84 mL |
| 50 mM | 0.06 mL | 0.28 mL | 0.57 mL |
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Product Datasheets for PKUMDL WQ 2201
References for PKUMDL WQ 2201
References are publications that support the biological activity of the product.
Wang et al (2017) Rational design of selective allosteric inhibitors of PHGDH and serine synthesis with anti-tumor activity. Cell Chem.Biol. 24 55 PMID: 28042046
If you know of a relevant reference for PKUMDL WQ 2201, please let us know.
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Keywords: PKUMDL WQ 2201, PKUMDL WQ 2201 supplier, PKUMDLWQ2201, PKUMDL-WQ-2201, PHGDH, 3-Phosphoglycerate, dehydrogenase, inhibitors, inhibits, negative, allosteric, modulators, anti-tumor, antitumor, NAM, Other, Dehydrogenases, 6581, Tocris Bioscience
Citations for PKUMDL WQ 2201
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