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Submit Review(+)-Abscisic Acid
Description: Endogenous LANCL2 agonist
Chemical Name: (2Z,4E)-5-[(1S)-1-Hydroxy-2,6,6-trimethyl-4-oxo-2-cyclohexen-1-yl]-3-methyl-2,4-pentadienoic acid
Purity: ≥98% (HPLC)
Biological Activity for (+)-Abscisic Acid
(+)-Abscisic Acid is an endogenous lanthionine synthetase C-like 2 (LANCL2) ligand. Stimulates glucose uptake by myocytes and pre-adipocytes in vitro, and by brown adipose tissue in vivo. Acts as a pro-inflammatory modulator of innate immune system cells. Stimulates proliferation of human mesenchymal and hematopoietic stem cells. Also used to control Cas9 via a RNA polymerase-based biosensor.
Technical Data for (+)-Abscisic Acid
| M. Wt | 264.32 |
| Formula | C15H20O4 |
| Storage | Store at -20°C |
| Purity | ≥98% (HPLC) |
| CAS Number | 21293-29-8 |
| PubChem ID | 5280896 |
| InChI Key | JLIDBLDQVAYHNE-YKALOCIXSA-N |
| Smiles | CC(/C=C/[C@]1(C(C)=CC(CC1(C)C)=O)O)=C/C(O)=O |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for (+)-Abscisic Acid
References for (+)-Abscisic Acid
References are publications that support the biological activity of the product.
Carbo et al (2016) An N,N-Bis(benzimidazolylpicolinoyl)piperazine (BT-11): A novel lanthionine synthetase C-Like 2-based therapeutic for inflammatory bowel disease. J.Med.Chem. 59 10113 PMID: 27933891
Fresia et al (2016) G-protein coupling and nuclear translocation of the human abscisic acid receptor LANCL2. Sci.Rep. 6 PMID: 27222287
Sturla et al (2017) Abscisic acid enhances glucose disposal and induces brown fat activity in adipocytes in vitro and in vivo. Biochim.Biophys.Acta. 1862 131 PMID: 27871880
Pu et al (2018) Multidimensional control of Cas9 by evolved RNA polymerase-based biosensors. ACS Chem.Biol. 13 431 PMID: 28809467
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Keywords: (+)-Abscisic Acid, (+)-Abscisic Acid supplier, LANCL2, agonists, ligands, ABA, Abscisic, acid, phytophormone, Other, Synthases/Synthetases, CRISPR, Reagents, 6554, Tocris Bioscience
1 Citation for (+)-Abscisic Acid
Citations are publications that use Tocris products. Selected citations for (+)-Abscisic Acid include:
Pengli et al (2022) Engineering receptors in the secretory pathway for orthogonal signalling control. Nat Commun 13 7350 PMID: 36446786
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