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Submit Review(+)-Anabasine hydrochloride
Discontinued Product
1971 has been discontinued.
View all Nicotinic Receptors (Non-selective) products.
Description: High affinity nAChR partial agonist
Chemical Name: (S)-(+)-3-(2-Piperidinyl)pyridine hydrochloride
Purity: ≥99% (HPLC)
Biological Activity for (+)-Anabasine hydrochloride
(+)-Anabasine hydrochloride is a high affinity neuronal nicotinic ACh receptor partial agonist (Ki values are 0.058, 0.26 and 7.2 μM for rat α7, rat α4β2 and fish skeletal muscle nAChRs respectively). Also stimulates Ca2+-dependent catecholamine release from rat adrenomedullary cells in vitro.
Technical Data for (+)-Anabasine hydrochloride
| M. Wt | 198.69 |
| Formula | C10H14N2.HCl |
| Storage | Desiccate at RT |
| Purity | ≥99% (HPLC) |
| CAS Number | 53912-89-3 |
| PubChem ID | 3041330 |
| InChI Key | VTMZQNZVYCJLGG-PPHPATTJSA-N |
| Smiles | [C@]1([C@H]2NCCCC2)=CC=CN=C1.Cl |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for (+)-Anabasine hydrochloride
References for (+)-Anabasine hydrochloride
References are publications that support the biological activity of the product.
Kem et al (1997) Anabaseine is a potent agonist on muscle and neuronal alpha-bungarotoxin-sensitive nicotinic receptors. J.Pharmacol.Exp.Ther. 283 979 PMID: 9399967
Parker et al (1998) Neuronal nicotinic receptor β2 and β4 subunits confer large differences in agonist binding affinity. Mol.Pharmacol. 54 1132 PMID: 9855644
Lu et al (1999) Desensitization of nicotinic agonist-induced [3H]γ-aminobutyric acid release from mouse brain synaptosomes is produced by subactivating concentrations of agonists. J.Pharmacol.Exp.Ther. 291 1127 PMID: 10565833
Hong et al (2007) Effect of anabasine on catecholamine secreation from the perfused rat adrenal medulla. J.Cardiol. 50 351 PMID: 18186309
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Keywords: (+)-Anabasine hydrochloride, (+)-Anabasine hydrochloride supplier, Neuronal, nicotinic, receptor, agonists, Acetylcholine, Receptors, Non-Selective, Subtypes, nAChR, Nicotinic, (Non-selective), 1971, Tocris Bioscience
Citations for (+)-Anabasine hydrochloride
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Currently there are no citations for (+)-Anabasine hydrochloride.
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Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
Nicotinic ACh Receptors Scientific Review
Updated in 2014, this review by Sue Wonnacott summarizes the diverse structure and function of nicotinic acetylcholine receptors and gives an in-depth review of the ligands available for nAChR research. Compounds available from Tocris are listed.