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Submit Review(+)-PD 128907 hydrochloride
Description: High affinity D3 agonist (D3 ≥ D2 > D4)
Chemical Name: (4aR,10bR)-3,4a,4,10b-Tetrahydro-4-propyl-2H,5H-[1]benzopyrano-[4,3-b]-1,4-oxazin-9-ol hydrochloride
Purity: ≥98% (HPLC)
Biological Activity for (+)-PD 128907 hydrochloride
(+)-PD 128907 hydrochloride is a high affinity D3 dopamine receptor agonist (Ki = 2.3 nM). Displays 18 - 200-fold selectivity over other dopamine receptor subtypes.
Technical Data for (+)-PD 128907 hydrochloride
| M. Wt | 285.77 |
| Formula | C14H19NO3.HCl |
| Storage | Store at +4°C |
| Purity | ≥98% (HPLC) |
| CAS Number | 300576-59-4 |
| PubChem ID | 11957668 |
| InChI Key | DCFXOTRONMKUJB-QMDUSEKHSA-N |
| Smiles | CCCN3[C@@H]2COC1=CC=C(O)C=C1[C@H]2OCC3.Cl |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for (+)-PD 128907 hydrochloride
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| water | 2.86 | 10 |
Preparing Stock Solutions for (+)-PD 128907 hydrochloride
The following data is based on the product molecular weight 285.77. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 34.99 mL | 174.97 mL | 349.93 mL |
| 0.5 mM | 7 mL | 34.99 mL | 69.99 mL |
| 1 mM | 3.5 mL | 17.5 mL | 34.99 mL |
| 5 mM | 0.7 mL | 3.5 mL | 7 mL |
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Product Datasheets for (+)-PD 128907 hydrochloride
References for (+)-PD 128907 hydrochloride
References are publications that support the biological activity of the product.
Bristow et al (1996) The behavioural and neurochemical profile of the putative DA D3 receptor agonist, (+)-PD 128907, in the rat. Neuropharmacology 35 285 PMID: 8783203
Pugsley et al (1995) Neurochemical and functional characterization of the preferentially selective DA D3 agonist PD 128907. J.Pharmacol.Exp.Ther. 275 1355 PMID: 8531103
Witkin et al (1998) Atypical antipsychotic-like effects of the DA D3 receptor agonist (+)-PD 128907. Eur.J.Pharmacol. 347 R1 PMID: 9741997
If you know of a relevant reference for (+)-PD 128907 hydrochloride, please let us know.
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Keywords: (+)-PD 128907 hydrochloride, (+)-PD 128907 hydrochloride supplier, D3, agonists, D2, D4, Dopamine, Receptors, dopaminergic, (+)-PD128907, hydrochloride, PD128907, 1243, Tocris Bioscience
9 Citations for (+)-PD 128907 hydrochloride
Citations are publications that use Tocris products. Selected citations for (+)-PD 128907 hydrochloride include:
Chai et al (2017) Neural Circuit-Specialized Astrocytes: Transcriptomic, Proteomic, Morphological, and Functional Evidence. Neuron 95 531 PMID: 28712653
Marcellino et al (2008) Identification of DA D1-D3 receptor heteromers. Indications for a role of synergistic D1-D3 receptor interactions in the striatum. Neurosci Lett 283 26016 PMID: 18644790
Cote and Kuzhikandathil (2015) Chronic lev. treatment alters expression and function of DA D3 receptor in the MPTP/p mouse model of Parkinson's disease. J Neurosci 585 33 PMID: 25445374
Schulz et al (2012) First and second generation antipsychotics influence hippocampal gamma oscillations by interactions with 5-HT3 and D3 receptors. Br J Pharmacol 167 1480 PMID: 22817643
Shin et al (2018) Drd3 Signaling in the Lateral Septum Mediates Early Life Stress-Induced Social Dysfunction. Neuron 97 195 PMID: 29276054
Basso et al (2005) Antidepressant-like effect of D(2/3) receptor-, but not D(4) receptor-activation in the rat forced swim test. Neuropsychopharmacology 30 1257 PMID: 15688083
Zapata et al (2007) Regulation of DA transporter function and cell surface expression by D3 DA receptors. J Biol Chem 282 35842 PMID: 17923483
Zhang et al (2004) Cocaine-induced intracellular signaling and gene expression are oppositely regulated by the DA D1 and D3 receptors. J Neurosci 24 3344 PMID: 15056714
Clemens and Hochman (2004) Conversion of the modulatory actions of DA on spinal reflexes from depression to facilitation in D3 receptor knock-out mice. J Neurosci 24 11337 PMID: 15601940
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Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
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Written by Phillip Strange and revised by Kim Neve in 2013, this review summarizes the history of the dopamine receptors and provides an overview of individual receptor subtype properties, their distribution and identifies ligands which act at each receptor subtype. Compounds available from Tocris are listed.
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