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Submit Review(+)-Tubocurarine chloride
Description: nAChR antagonist
Chemical Name: 2,3,13a,14,15,16,25,25a,-Octahydro-9,19-dihydroxy-18,29-dimethoxy-1,14,14-trimethyl-13H-4,6:21,24-dietheno-8,12-metheno-1H-pyrido[3',2':14,15][1,11]dioxacycloeicosino[2,3,4-ij]isoquinolinium chloride hydrochloride
Purity: ≥98% (HPLC)
Biological Activity for (+)-Tubocurarine chloride
(+)-Tubocurarine chloride is a competitive, non-selective nicotinic acetylcholine receptor antagonist; causes skeletal muscle relaxation. Also a 5-HT3 and GABAA receptor antagonist.
Technical Data for (+)-Tubocurarine chloride
| M. Wt | 681.65 |
| Formula | C37H41ClN2O6.HCl |
| Storage | Store at +4°C |
| Purity | ≥98% (HPLC) |
| CAS Number | 57-94-3 |
| PubChem ID | 64645 |
| InChI Key | GXFZCDMWGMFGFL-KKXMJGKMSA-N |
| Smiles | OC1=C(OC)C=C3C([C@@H]7[N+](C)(C)CC3)=C1OC(C=C5)=CC=C5C[C@H](N(C)CC4)C2=C4C=C(OC)C(OC6=C(O)C=CC(C7)=C6)=C2.[Cl-].Cl |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for (+)-Tubocurarine chloride
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| water | 17.04 | 25 |
Preparing Stock Solutions for (+)-Tubocurarine chloride
The following data is based on the product molecular weight 681.65. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.25 mM | 5.87 mL | 29.34 mL | 58.68 mL |
| 1.25 mM | 1.17 mL | 5.87 mL | 11.74 mL |
| 2.5 mM | 0.59 mL | 2.93 mL | 5.87 mL |
| 12.5 mM | 0.12 mL | 0.59 mL | 1.17 mL |
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Product Datasheets for (+)-Tubocurarine chloride
References for (+)-Tubocurarine chloride
References are publications that support the biological activity of the product.
Pederson and Cohen (1990) d-Tucocurarine binding sites are located at α-γ and α-δ subunit interfaces of the nicotinic acetylcholine receptor. Proc.Natl.Acad.Sci.USA 87 2785
Peters et al (1990) Antagonism of 5-HT3 receptor mediated currents in murine N1E-115 neuroblastoma cells by (+)-tubocurarine. Neurosci.Letts. 110 107
Wotring and Yoon (1995) The inhibitory effects of nicotinic antagonists on currents elicited by GABA in rat hippocampal neurons. Neurosci. 67 293
If you know of a relevant reference for (+)-Tubocurarine chloride, please let us know.
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Keywords: (+)-Tubocurarine chloride, (+)-Tubocurarine chloride supplier, Nicotinic, receptor, antagonists, Acetylcholine, Receptors, Non-Selective, Subtypes, nAChR, curare, (Non-selective), 2820, Tocris Bioscience
10 Citations for (+)-Tubocurarine chloride
Citations are publications that use Tocris products. Selected citations for (+)-Tubocurarine chloride include:
Truszkowski et al (2017) A cellular mechanism for inverse effectiveness in multisensory integration. Elife 6 PMID: 28315524
Zachary and Fuchs (2015) Re-Emergent Inhibition of Cochlear Inner Hair Cells in a Mouse Model of Hearing Loss. J Neurosci 35 9701 PMID: 26134652
Freeman et al (2013) Picrotoxin dramatically speeds the mammalian circadian clock independent of Cys-loop receptors. Front Behav Neurosci 110 103 PMID: 23576702
Zhu et al (2017) Impairments of spatial memory in an Alzheimer's disease model via degeneration of hippocampal cholinergic synapses. Nat Commun 8 1676 PMID: 29162816
Nagel et al (2015) Synaptic and circuit mechanisms promoting broadband transmission of olfactory stimulus dynamics. Nat Neurosci 18 56 PMID: 25485755
Roemmich et al (2018) Ex vivo Whole-cell Recordings in Adult Drosophila Brain. Bio Protoc 8 PMID: 30148187
Saliba et al (2012) Activity-dependent phosphorylation of GABAA receptors regulates receptor insertion and tonic current. J Biol Chem 31 2937 PMID: 22531784
Lamy et al (2010) Allosteric block of KCa2 channels by apamin. J Neurophysiol 285 27067 PMID: 20562108
Pinnock et al (2015) Nicotine receptors mediating sensorimotor gating and its enhancement by systemic nicotine. BMC Syst Biol 9 30 PMID: 25717295
Corns et al (2018) Mechanotransduction is required for establishing and maintaining mature inner hair cells and regulating efferent innervation. Nat Commun 9 4015 PMID: 30275467
Do you know of a great paper that uses (+)-Tubocurarine chloride from Tocris? Please let us know.
Reviews for (+)-Tubocurarine chloride
Average Rating: 5 (Based on 1 Review.)
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Neuromuscular blocking drugs.
By
Anonymous on 02/16/2018
Assay Type: In Vivo
Species: Other
We use 2 mg of tubocurarine in a demonstration experiment to review its properties as a neuromuscular blocking drug
To emphasize its action mechanism is useful to compare it with 2 mg of Succinylcholine in a chicken model
Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
Nicotinic ACh Receptors Scientific Review
Updated in 2014, this review by Sue Wonnacott summarizes the diverse structure and function of nicotinic acetylcholine receptors and gives an in-depth review of the ligands available for nAChR research. Compounds available from Tocris are listed.