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Submit ReviewPMX 464
Description: Putative inhibitor of the Trx-TrxR system; antiproliferative
Chemical Name: 4-(2-Benzothiazolyl)-4-hydroxy-2,5-cyclohexadien-1-one
Purity: ≥98% (HPLC)
Biological Activity for PMX 464
PMX 464 is a putative inhibitor of the thioredoxin-thioredoxin reductase (Trx-TrxR) system. Shown to inhibit Trx and induce a G1/S block in HT29 cells; inhibits cell proliferation in various colorectal cancer cell lines and MCF7 cells. Also elicits an anti-inflammatory response in A549 cells.
Technical Data for PMX 464
| M. Wt | 243.28 |
| Formula | C13H9NO2S |
| Storage | Store at -20°C |
| Purity | ≥98% (HPLC) |
| CAS Number | 485842-97-5 |
| PubChem ID | 482697 |
| InChI Key | SDYBYKXWYDVVKP-UHFFFAOYSA-N |
| Smiles | O=C(C=C3)C=CC3(O)C2=NC1=CC=CC=C1S2 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for PMX 464
References for PMX 464
References are publications that support the biological activity of the product.
Mukherjee et al (2007) A cellular and molecular investigation of the action of PMX464, a putative thioredoxin inhibitor, in normal and colorectal cancer cell lines. Br.J.Pharmacol. 151 1167 PMID: 17572693
Callister et al (2008) PMX464, a thiol-reactive quinol and putative thioredoxin inhibitor, inhibits NF-κB-dependent proinflammatory activation of alveolar epithelial cells. Br.J.Pharmacol. 155 661 PMID: 18587424
Mukherjee et al (2005) Cytotoxic and antiangiogenic activity of AW464 (NSC 706704), a novel thioredoxin inhibitor: an in vitro study. Br.J.Cancer 92 350 PMID: 15655539
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Keywords: PMX 464, PMX 464 supplier, PMX464, PMX_464, antiproliferative, thioredoxin, reductase, TrxR, Trx1, inhibitors, inhibits, cell, proliferation, Thioredoxin, Reductases, 4996, Tocris Bioscience
1 Citation for PMX 464
Citations are publications that use Tocris products. Selected citations for PMX 464 include:
Schroeder (2017) Targeting Thioredoxin-1 by dimethyl fumarate induces ripoptosome-mediated cell death Sci Rep 7 43168 PMID: 28233787
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