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Submit ReviewPNU 177864 hydrochloride
Description: Highly selective D3 antagonist
Chemical Name: N-[4-[2-(Propylamino)ethyl)phenyl]-4-(trifluoromethoxy)-benzenesulfonamide hydrochloride
Purity: ≥99% (HPLC)
Biological Activity for PNU 177864 hydrochloride
PNU 177864 hydrochloride is a highly selective dopamine D3 receptor antagonist. Induces phospholipidosis and exhibits antischizophrenic activity in vivo.
Technical Data for PNU 177864 hydrochloride
| M. Wt | 438.89 |
| Formula | C18H21F3N2O3S.HCl |
| Storage | Desiccate at RT |
| Purity | ≥99% (HPLC) |
| CAS Number | 1783978-03-9 |
| PubChem ID | 56972219 |
| InChI Key | UOMDLHQTLPWCCE-UHFFFAOYSA-N |
| Smiles | O=S(C1=CC=C(OC(F)(F)F)C=C1)(NC2=CC=C(CCNCCC)C=C2)=O.Cl |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for PNU 177864 hydrochloride
References for PNU 177864 hydrochloride
References are publications that support the biological activity of the product.
Vonderfecht et al (2004) Myopathy related to administration of a cationic amphiphilic drug and the use of multidose drug distribution analysis to predict its occurrence. Toxicol.Pathol. 32 318 PMID: 15204973
Rudmann et al (2004) Epididymal and systemic phospholipidosis in rats and dogs treated with DA D3 selective antagonist PNU-177864. Toxicol.Pathol. 32 326 PMID: 15204974
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Citations for PNU 177864 hydrochloride
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Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
Dopamine Receptors Scientific Review
Written by Phillip Strange and revised by Kim Neve in 2013, this review summarizes the history of the dopamine receptors and provides an overview of individual receptor subtype properties, their distribution and identifies ligands which act at each receptor subtype. Compounds available from Tocris are listed.
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