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Submit ReviewProbenecid
Description: MRP and OAT3 inhibitor
Chemical Name: 4-(Dipropylsulfamoyl)benzoic acid
Purity: ≥98% (HPLC)
Biological Activity for Probenecid
Probenecid is an inhibitor of multidrug resistance-associated proteins (MRP). Probenicid inhibits OAT3, organic acid transport in the kidney and other organs and exhibits inhibitory activity against pannexin 1 channels (IC50 ~ 150 μM). Probenecid potently inhibits SARS-CoV-2 replication in NHBE and Vero E6 cells (IC50 = 1.3 nM and 750 nM, respectively) and reduces lung virus titers in vivo. Probenicid also inhibits influenza A virus replication in vitro and in vivo.
Compound Libraries for Probenecid
Probenecid is also offered as part of the Tocriscreen 2.0 Max, Tocriscreen Antiviral Library and Tocriscreen FDA-Approved Drugs. Find out more about compound libraries available from Tocris.
Technical Data for Probenecid
| M. Wt | 285.36 |
| Formula | C13H19NO4S |
| Storage | Store at RT |
| Purity | ≥98% (HPLC) |
| CAS Number | 57-66-9 |
| PubChem ID | 4911 |
| InChI Key | DBABZHXKTCFAPX-UHFFFAOYSA-N |
| Smiles | O=S(C1=CC=C(C(O)=O)C=C1)(N(CCC)CCC)=O |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for Probenecid
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 28.54 | 100 | |
| ethanol | 28.54 | 100 |
Preparing Stock Solutions for Probenecid
The following data is based on the product molecular weight 285.36. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 3.5 mL | 17.52 mL | 35.04 mL |
| 5 mM | 0.7 mL | 3.5 mL | 7.01 mL |
| 10 mM | 0.35 mL | 1.75 mL | 3.5 mL |
| 50 mM | 0.07 mL | 0.35 mL | 0.7 mL |
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Product Datasheets for Probenecid
References for Probenecid
References are publications that support the biological activity of the product.
Cunningham et al (1981) Clinical pharmacokinetics of probe. Clin.Pharmacokinet. 6 135 PMID: 7011657
Hammond et al (2007) Glutathione export during apoptosis requires functional multidrug resistance-associated proteins. J.Biol.Chem. 282 14337 PMID: 17374608
Silverman et al (2008) Probenecid, a gout remedy, inhibits pannexin 1 channels. Am.J.Physiol.Cell Physiol. 295 C761 PMID: 18596212
Ishikawa et al (2010) Function and expression of ATP-binding cassette transporters in cultured human Y79 retinoblastoma cells. Biol.Pharm.Bull. 33 504 PMID: 20190417
Perwitasai et al (2013) Targeting organic anion transporter 3 with probenecid as a novel anti-influenza a virus strategy. Antimicrob.Agents Chemother. 57 475 PMID: 23129053
Murray et al (2021) Probenecid inhibits SARS-CoV-2 replication in vivo and in vitro. Sci.Rep. 11 PMID: 34508172
If you know of a relevant reference for Probenecid, please let us know.
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Keywords: Probenecid, Probenecid supplier, ATP-binding, cassette, ABC, multidrug, resistance-associated, proteins, MRP, inhibitors, inhibits, Multidrug, Transporters, Influenza, Viruses, COVID-19, Coronavirus, 4107, Tocris Bioscience
4 Citations for Probenecid
Citations are publications that use Tocris products. Selected citations for Probenecid include:
Ostrovskaya et al (2014) Neuroprotective effect of novel cognitive enhancer noopept on AD-related cellular model involves the attenuation of apoptosis and tau hyperphosphorylation. J Biomed Sci 21 74 PMID: 25096780
Juan V et al (2021) Abacavir Increases Purinergic P2X7 Receptor Activation by ATP: Does a Pro-inflammatory Synergism Underlie Its Cardiovascular Toxicity? Front Pharmacol 12 613449 PMID: 33867979
Asgari et al (2013) C3a modulates IL-1β secretion in human monocytes by regulating ATP efflux and subsequent NLRP3 inflammasome activation. J Biol Chem 122 3473 PMID: 23878142
Anna et al (2017) The Effect of N-Terminal Cyclization on the Function of the HIV Entry Inhibitor 5P12-RANTES. Int J Mol Sci 18 PMID: 28726743
Do you know of a great paper that uses Probenecid from Tocris? Please let us know.
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Literature in this Area
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