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Submit ReviewProcaterol hydrochloride
Description: Potent β2 agonist
Chemical Name: (±)-erythro-8-Hydroxy-5-[1-hydroxy-2-(isopropylamino)butyl]carbostyril hydrochloride
Purity: ≥99% (HPLC)
Biological Activity for Procaterol hydrochloride
Procaterol hydrochloride is a specific and very potent β2 agonist.
Compound Libraries for Procaterol hydrochloride
Procaterol hydrochloride is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.
Technical Data for Procaterol hydrochloride
| M. Wt | 326.82 |
| Formula | C16H22N2O3.HCl |
| Storage | Store at RT |
| Purity | ≥99% (HPLC) |
| CAS Number | 62929-91-3 |
| PubChem ID | 43091 |
| InChI Key | AEQDBKHAAWUCMT-CVHDTDHSSA-N |
| Smiles | O=C1C=CC2=C(C(O)=CC=C2[C@@]([H])(O)[C@@](NC(C)C)(CC)[H])N1.Cl |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for Procaterol hydrochloride
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| water | 32.68 | 100 | |
| DMSO | 32.68 | 100 |
Preparing Stock Solutions for Procaterol hydrochloride
The following data is based on the product molecular weight 326.82. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 3.06 mL | 15.3 mL | 30.6 mL |
| 5 mM | 0.61 mL | 3.06 mL | 6.12 mL |
| 10 mM | 0.31 mL | 1.53 mL | 3.06 mL |
| 50 mM | 0.06 mL | 0.31 mL | 0.61 mL |
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Product Datasheets for Procaterol hydrochloride
References for Procaterol hydrochloride
References are publications that support the biological activity of the product.
Kotsonis and Majewski (1994) Facilitation by procaterol, a β-adrenoceptor agonist, of noradrenaline release in the pithed rat independently of angiotensin II formation. Br.J.Pharmacol. 113 781 PMID: 7858867
Lakhlani et al (1994) Pharmacological characterization and anatomical localization of prejunctional β-adrenoceptors in the rat kidney. Br.J.Pharmacol. 111 1296 PMID: 8032617
Yoshizaki et al (1976) Sympathomimetic amines having a carbostyril nucleus. J.Med.Chem. 19 1138 PMID: 10441
Yoshizaki et al (1977) Isomers of erythro-5-(1-hydroxy-2-isoproylaminobutyl)-8-hydroxycarbostyril, a new bronchodilator. J.Med.Chem. 20 1103 PMID: 894683
If you know of a relevant reference for Procaterol hydrochloride, please let us know.
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5 Citations for Procaterol hydrochloride
Citations are publications that use Tocris products. Selected citations for Procaterol hydrochloride include:
Schutsky et al (2011) Stress and glucocorticoids impair memory retrieval via β2-adrenergic, Gi/o-coupled suppression of cAMP signaling. J Neurosci 31 14172 PMID: 21976502
Sivamani et al (2009) Stress-mediated increases in systemic and local epinephrine impair skin wound healing: potential new indication for β blockers. J Pharmacol Exp Ther 6 e12 PMID: 19143471
Kaya et al (2009) Coupling of β2-adrenoceptors to XLαs and Gαs: a new insight into ligand-induced G protein activation. Front Cell Neurosci 329 350 PMID: 19144685
Copik et al (2015) Isoproterenol acts as a biased agonist of the α-1A-adrenoceptor that selectively activates the MAPK/ERK pathway. PLoS Med 10 e0115701 PMID: 25606852
Rieg et al (2012) Cardiovascular agents affect the tone of pulmonary arteries and veins in precision-cut lung slices. PLoS One 6 e29698 PMID: 22216346
Do you know of a great paper that uses Procaterol hydrochloride from Tocris? Please let us know.
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Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
Depression Poster
Major depressive disorder is characterized by depressed mood and a loss of interest and/or pleasure. Updated in 2015 this poster highlights presynaptic and postsynaptic targets for the potential treatment of major depressive disorder, as well as outlining the pharmacology of currently approved antidepressant drugs.