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Proglumide sodium salt

Cat. No. 1478 1 Citation Submit a Review Datasheet / COA / SDS
Pricing Availability   Qty
Description: Non-selective CCK antagonist; orally active
Chemical Name: 4-(Benzoylamino)-5-(dipropylamino)-5-oxopentanoic acid sodium salt
Purity: ≥98% (HPLC)
Datasheet
Citations (1)
Reviews
Literature (1)
Biological Activity Technical Data Solubility Calculators Datasheets References

Biological Activity for Proglumide sodium salt

Proglumide sodium salt is a non-selective cholecystokinin (CCK) antagonist. Inhibits CCK-stimulated amylase secretion and prevents CCK-induced 2-deoxyglucose uptake in mouse pancreatic acini. Blocks growth of HT29 colon carcinoma cells in response to gastrin 17 treatment. Orally active.

Technical Data for Proglumide sodium salt

M. Wt 356.39
Formula C18H25N2NaO4
Storage Desiccate at RT
Purity ≥98% (HPLC)
CAS Number 99247-33-3
PubChem ID 23677833
InChI Key UFMWGCINVOIJSO-UHFFFAOYSA-M
Smiles [Na+].CCCN(CCC)C(=O)C(CCC([O-])=O)NC(=O)C1=CC=CC=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for Proglumide sodium salt

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
water 35.64 100

Preparing Stock Solutions for Proglumide sodium salt

The following data is based on the product molecular weight 356.39. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.81 mL 14.03 mL 28.06 mL
5 mM 0.56 mL 2.81 mL 5.61 mL
10 mM 0.28 mL 1.4 mL 2.81 mL
50 mM 0.06 mL 0.28 mL 0.56 mL

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Product Datasheets for Proglumide sodium salt

Certificate of Analysis / Product Datasheet
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Safety Datasheet

References for Proglumide sodium salt

References are publications that support the biological activity of the product.

Iwamoto et al (1984) In vitro and in vivo effect of proglumide on cholecystokinin-stimulated amylase release in mouse pancreatic acini. Gastroenterol.Jpn. 19 53 PMID: 6202584

Mauss et al (1994) Effects of gastrin, proglumide, loxiglumide and L-365,260 on growth of human colon carcinoma cells. Anticancer Res. 14 215 PMID: 8166452

Hahne et al (1981) Proglumide and benzotript: members of a different class of cholecystokinin receptor antagonists. Proc.Natl.Acad.Sci.U.S.A. 78 6304 PMID: 6171817

If you know of a relevant reference for Proglumide sodium salt, please let us know.

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1 Citation for Proglumide sodium salt

Citations are publications that use Tocris products. Selected citations for Proglumide sodium salt include:

Shivapurkar et al (2023) Treatment with a Cholecystokinin Receptor Antagonist, Proglumide, Improves Efficacy of Immune Checkpoint Antibodies in Hepatocellular Carcinoma Int J Mol Sci 24 3625

Do you know of a great paper that uses Proglumide sodium salt from Tocris? Please let us know.

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Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

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Peptides Involved in Appetite Modulation Scientific Review

Peptides Involved in Appetite Modulation Scientific Review

Written by Sonia Tucci, Lynsay Kobelis and Tim Kirkham, this review provides a synopsis of the increasing number of peptides that have been implicated in appetite regulation and energy homeostasis; putative roles of the major peptides are outlined and compounds available from Tocris are listed.