Submit a Review & Earn an Amazon Gift Card
You can now submit reviews for your favorite Tocris products. Your review will help other researchers decide on the best products for their research. Why not submit a review today?!
Submit ReviewPSB 0777 ammonium salt
Description: Potent adenosine A2A agonist
Chemical Name: 4-[2-[(6-Amino-9-b-D-ribofuranosyl-9H-purin-2-yl)thio]ethyl]benzenesulfonic acid ammonium salt
Purity: ≥97% (HPLC)
Biological Activity for PSB 0777 ammonium salt
PSB 0777 ammonium salt is a potent adenosine A2A receptor full agonist (Ki = 44.4 nM for rat brain striatal A2A receptors). Exhibits subtype selectivity for A2A receptors over A1, A2B and A3 receptors (Ki ≥ 10 000 nM for rat A1, human A2B and human A3 receptors). Potentiates acetylcholine-induced contractions in ex vivo rat ileum/jejunum segments.
Compound Libraries for PSB 0777 ammonium salt
PSB 0777 ammonium salt is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.
Technical Data for PSB 0777 ammonium salt
| M. Wt | 500.55 |
| Formula | C18H20N5O7S2.NH4 |
| Storage | Store at RT |
| Purity | ≥97% (HPLC) |
| CAS Number | 2122196-16-9 |
| PubChem ID | 90488932 |
| InChI Key | AYQGFWKUGKSGCZ-VSAOVUCUSA-N |
| Smiles | NC1=C3C(N([C@@H]4O[C@H](CO)[C@@H](O)[C@@H]4O)C=N3)=NC(SCCC2=CC=C(S(=O)(O)=O)C=C2)=N1.N |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for PSB 0777 ammonium salt
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| water | 50.05 | 100 | |
| DMSO | 50.05 | 100 |
Preparing Stock Solutions for PSB 0777 ammonium salt
The following data is based on the product molecular weight 500.55. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2 mL | 9.99 mL | 19.98 mL |
| 5 mM | 0.4 mL | 2 mL | 4 mL |
| 10 mM | 0.2 mL | 1 mL | 2 mL |
| 50 mM | 0.04 mL | 0.2 mL | 0.4 mL |
Molarity Calculator
Molarity Calculator
Calculate the mass, volume, or concentration required for a solution.
Reconstitution Calculator
Reconstitution Calculator
Dilution Calculator
Dilution Calculator
Calculate the dilution required to prepare a stock solution.
Product Datasheets for PSB 0777 ammonium salt
References for PSB 0777 ammonium salt
References are publications that support the biological activity of the product.
El-Tayeb et al (2012) Development of polar adenosine A2A receptor agonists for inflammatory bowel disease: synergism with A2B antagonists. ACS Med.Chem.Lett. 2 890 PMID: 24900277
If you know of a relevant reference for PSB 0777 ammonium salt, please let us know.
View Related Products by Target
View Related Products by Product Action
Keywords: PSB 0777 ammonium salt, PSB 0777 ammonium salt supplier, Adenosine, A2A, receptors, agonists, potent, subtypes, selective, PSB0777, ammonium, salt, Receptors, 4334, Tocris Bioscience
2 Citations for PSB 0777 ammonium salt
Citations are publications that use Tocris products. Selected citations for PSB 0777 ammonium salt include:
Gemma et al (2020) Experimental and computational analysis of biased agonism on full-length and a C-terminally truncated adenosine A2A receptor. Comput Struct Biotechnol J 18 2723-2732 PMID: 33101610
Cezary et al (2020) Adenosine Receptor Agonists Increase the Inhibition of Platelet Function by P2Y12 Antagonists in a cAMP- and Calcium-Dependent Manner. Pharmaceuticals (Basel) 13 PMID: 32752089
Do you know of a great paper that uses PSB 0777 ammonium salt from Tocris? Please let us know.
Reviews for PSB 0777 ammonium salt
There are currently no reviews for this product. Be the first to review PSB 0777 ammonium salt and earn rewards!
Have you used PSB 0777 ammonium salt?
Submit a review and receive an Amazon gift card.
$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image
$25/€18/£15/$25CAN/¥75 Yuan/¥2500 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image
Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
Parkinson's Disease Poster
Parkinson's disease (PD) causes chronic disability and is the second most common neurodegenerative condition. This poster outlines the neurobiology of the disease, as well as highlighting current therapeutic treatments for symptomatic PD, and emerging therapeutic strategies to delay PD onset and progression.