Submit a Review & Earn an Amazon Gift Card
You can now submit reviews for your favorite Tocris products. Your review will help other researchers decide on the best products for their research. Why not submit a review today?!
Submit ReviewPSB 1115
Description: Selective human A2B antagonist; water-soluble
Chemical Name: 4-(2,3,6,7-Tetrahydro-2,6-dioxo-1-propyl-1H-purin-8-yl)-benzenesulfonic acid
Purity: ≥98% (HPLC)
Biological Activity for PSB 1115
PSB 1115 is a highly selective, water-soluble, human A2B adenosine receptor antagonist. Ki values are 53.4, > 10000 and > 10000 nM at human A2B, A1 and A3 receptors respectively. Also selective versus rat A1 and A2A receptors (Ki values are 2200 and 24000 nM respectively). Produces potent analgesic effects in vivo.
Compound Libraries for PSB 1115
PSB 1115 is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.
Technical Data for PSB 1115
| M. Wt | 350.35 |
| Formula | C14H14N4O5S |
| Storage | Store at RT |
| Purity | ≥98% (HPLC) |
| CAS Number | 152529-79-8 |
| PubChem ID | 5311479 |
| InChI Key | UYDRRQPGDSIMNU-UHFFFAOYSA-N |
| Smiles | O=C(NC2=C1NC(C3=CC=C(S(=O)(O)=O)C=C3)=N2)N(CCC)C1=O |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for PSB 1115
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 38.84 | 100 | |
| water | 7.77 | 20 with gentle warming |
Preparing Stock Solutions for PSB 1115
The following data is based on the product molecular weight 350.35. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.85 mL | 14.27 mL | 28.54 mL |
| 5 mM | 0.57 mL | 2.85 mL | 5.71 mL |
| 10 mM | 0.29 mL | 1.43 mL | 2.85 mL |
| 50 mM | 0.06 mL | 0.29 mL | 0.57 mL |
Molarity Calculator
Molarity Calculator
Calculate the mass, volume, or concentration required for a solution.
Reconstitution Calculator
Reconstitution Calculator
Dilution Calculator
Dilution Calculator
Calculate the dilution required to prepare a stock solution.
Product Datasheets for PSB 1115
References for PSB 1115
References are publications that support the biological activity of the product.
Muller et al (1998) 8-(Sulfostyryl)xanthines: water-soluble A2A-selective adenosine receptor antagonists. Bioorg.Med.Chem. 6 707 PMID: 9681137
Hayallah et al (2002) 1,8-Disubstituted xanthine derivatives: synthesis of potent A2B-selective adenosine receptor antagonists. J.Med.Chem. 45 1500 PMID: 11906291
Abo-Salem et al (2004) Antinociceptive effects of novel A2B adenosine receptor antagonists. J.Pharmacol.Exp.Ther. 308 358 PMID: 14563788
Yan and Muller (2004) Preparation, properties, reactions, and adenosine receptor affinities of sulfophenylxanthine nitrophenyl esters: toward the development of sulfonic acid prodrugs with peroral bioavailability. J.Med.Chem. 47 1031 PMID: 14761205
If you know of a relevant reference for PSB 1115, please let us know.
View Related Products by Target
View Related Products by Product Action
Keywords: PSB 1115, PSB 1115 supplier, Selective, human, A2B, receptors, antagonists, water-soluble, adenosines, PSB1115, Adenosine, Receptors, 2009, Tocris Bioscience
10 Citations for PSB 1115
Citations are publications that use Tocris products. Selected citations for PSB 1115 include:
Rao et al (2014) A dual role for autophagy in a murine model of lung cancer. Proc Natl Acad Sci U S A 5 3056 PMID: 24445999
Chia et al (2013) The protective effects of CD39 overexpression in multiple low-dose streptozotocin-induced diabetes in mice. J Clin Invest 62 2026 PMID: 23364452
Hua et al (2011) IL-4 amplifies the pro-inflammatory effect of adenosine in human mast cells by changing expression levels of adenosine receptors. PLoS One 6 e24947 PMID: 21966389
Eckle et al (2008) A2B adenosine receptor signaling attenuates acute lung injury by enhancing alveolar fluid clearance in mice. J Immunol 118 3301 PMID: 18787641
Frick et al (2009) Contribution of adenosine A2B receptors to inflammatory parameters of experimental colitis. J Pharmacol Exp Ther 182 4957 PMID: 19342675
Hart et al (2009) Cutting Edge: A2B Adenosine receptor signaling provides potent protection during intestinal ischemia/reperfusion injury. Diabetes 182 3965 PMID: 19299692
Iannone et al (2013) Blockade of A2b adenosine receptor reduces tumor growth and immune suppression mediated by myeloid-derived suppressor cells in a mouse model of melanoma. Neoplasia 15 1400 PMID: 24403862
Sassi et al (2014) Cardiac myocyte-secreted cAMP exerts paracrine action via adenosine receptor activation. J Clin Invest 124 5385 PMID: 25401477
Stagg et al (2010) Anti-CD73 antibody therapy inhibits breast tumor growth and metastasis. J Immunol 107 1547 PMID: 20080644
Ning et al (2014) Excess adenosine A2B receptor signaling contributes to priapism through HIF-1α mediated reduction of PDE5 gene expression. FASEB J 28 2725 PMID: 24614760
Do you know of a great paper that uses PSB 1115 from Tocris? Please let us know.
Reviews for PSB 1115
There are currently no reviews for this product. Be the first to review PSB 1115 and earn rewards!
Have you used PSB 1115?
Submit a review and receive an Amazon gift card.
$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image
$25/€18/£15/$25CAN/¥75 Yuan/¥2500 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image