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Submit ReviewPSB 603
Description: Highly selective A2B antagonist
Chemical Name: 8-[4-[4-(4-Chlorophenzyl)piperazide-1-sulfonyl)phenyl]]-1-propylxanthine
Purity: ≥98% (HPLC)
Biological Activity for PSB 603
PSB 603 is an adenosine A2B receptor antagonist that displays > 17000-fold selectivity over other adenosine receptors (Ki values are 0.553, > 10000, > 10000 and > 10000 nM for A2B, A1, A2A and A3 receptors respectively). Downregulates the expression of osteocalcin and osteopontin during osteogenic differentiation of mesenchymal stem cells.
Compound Libraries for PSB 603
PSB 603 is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.
Technical Data for PSB 603
| M. Wt | 529.01 |
| Formula | C24H25ClN6O4S |
| Storage | Store at +4°C |
| Purity | ≥98% (HPLC) |
| CAS Number | 1092351-10-4 |
| PubChem ID | 44185871 |
| InChI Key | OVHCTHHFOHMNFV-UHFFFAOYSA-N |
| Smiles | O=C(NC2=C1NC(C3=CC=C(S(N4CCN(C5=CC=C(Cl)C=C5)CC4)(=O)=O)C=C3)=N2)N(CCC)C1=O |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for PSB 603
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 26.45 | 50 |
Preparing Stock Solutions for PSB 603
The following data is based on the product molecular weight 529.01. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.5 mM | 3.78 mL | 18.9 mL | 37.81 mL |
| 2.5 mM | 0.76 mL | 3.78 mL | 7.56 mL |
| 5 mM | 0.38 mL | 1.89 mL | 3.78 mL |
| 25 mM | 0.08 mL | 0.38 mL | 0.76 mL |
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Product Datasheets for PSB 603
References for PSB 603
References are publications that support the biological activity of the product.
Borrmann et al (2009) 1-alkyl-8-(piperazine-1-sulfonyl)phenylxanthines: development and characterization of adenosine A2B receptor antagonists and a new radioligand with subnanomolar affinity and subtype specificity. J.Med.Chem. 52 3994 PMID: 19569717
Shih et al (2014) Calcium phosphate-bearing matrices induce osteogenic differentiation of stem cells through adenosine signaling. Proc.Natl.Acad.Sci.U.S.A. 111 990 PMID: 24395775
If you know of a relevant reference for PSB 603, please let us know.
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Keywords: PSB 603, PSB 603 supplier, selective, A2B, antagonists, Receptors, adenosines, PSB603, osteogenic, stem, cell, differentiation, Adenosine, 3198, Tocris Bioscience
6 Citations for PSB 603
Citations are publications that use Tocris products. Selected citations for PSB 603 include:
Stoddart et al (2015) Application of BRET to monitor ligand binding to GPCRs. Nat Methods 12 661 PMID: 26030448
Rao et al (2015) Adenosine Signaling Mediates Osteogenic Differentiation of Human Embryonic Stem Cells on Mineralized Matrices. Front Bioeng Biotechnol 3 185 PMID: 26618155
Kang et al (2016) Small molecule-driven direct conversion of human pluripotent stem cells into functional osteoblasts. Sci Adv 2 e1600691 PMID: 27602403
Ham et al (2010) Endogenous luminal surface adenosine signaling regulates duodenal bicarbonate secretion in rats. Proc Natl Acad Sci U S A 335 607 PMID: 20805305
Schneider et al (2015) Extracellular nucleotides as novel, underappreciated pro-metastatic factors that stimulate purinergic signaling in human lung cancer cells. Oncogene 14 201 PMID: 26597723
Long et al (2015) p73 engages A2B receptor signalling to prime cancer cells to chemotherapy-induced death. J Pharmacol Exp Ther 34 5152 PMID: 25659586
Do you know of a great paper that uses PSB 603 from Tocris? Please let us know.
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