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Submit ReviewPTAC oxalate
Description: Muscarinic receptor ligand; exhibits partial agonist and antagonist activity at different subtypes
Chemical Name: (1R,5R,6R)-6-[4-(Propylthio)-1,2,5-thiadiazol-3-yl]-1-azabicyclo[3.2.1]octane oxalate
Purity: ≥98% (HPLC)
Biological Activity for PTAC oxalate
PTAC oxalate is a muscarinic receptor ligand. Displays partial agonist activity at M2 and M4 receptors; exhibits antagonist effects at M1, M3 and M5 receptors (Ki values are 2.8, 0.2, 0.6, 0.2 and 0.8 nM respectively). Displays selectivity for muscarinic receptors over a range of neurotransmitter receptors and ion channels. Inhibits firing rate of dopaminergic cells in the limbic ventral tegmental area after acute administration, without binding to dopamine receptors.
Technical Data for PTAC oxalate
| M. Wt | 359.46 |
| Formula | C12H19N3S2.C2H2O4 |
| Storage | Desiccate at RT |
| Purity | ≥98% (HPLC) |
| CAS Number | 201939-40-4 |
| PubChem ID | 90488949 |
| InChI Key | LXXQOVMTAFXOKQ-IYPAPVHQSA-N |
| Smiles | CCCSC1=NSN=[C@]1[C@@H]2[C@H]3CCCN(C3)C2.O=C(C(O)=O)O |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for PTAC oxalate
References for PTAC oxalate
References are publications that support the biological activity of the product.
Raedler et al (2007) Towards a muscarinic hypothesis of schizophrenia. Mol.Psychiatry 12 232 PMID: 17146471
Shannon et al (1999) Muscarinic receptor agonists, like DA receptor antagonist antipsychotics, inhibit conditioned avoidance response in rats. J.Pharmacol.Exp.Ther. 290 901 PMID: 10411607
Bymaster et al (1998) Unexpected antipsychotic-like activity with the muscarinic receptor ligand (5R,6R)6-(3-propylthio-1,2,5-thiadiazol-4-yl)-1-azabicyclo[3.2.1]octane. Eur.J.Pharmacol. 356 109 PMID: 9774240
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Keywords: PTAC oxalate, PTAC oxalate supplier, PTAC, antipsychotics, schizophrenia, selective, muscarinic, partial, agonists, antagonists, M1, M2, M3, M4, M5, Non-selective, Muscarinics, 4533, Tocris Bioscience
1 Citation for PTAC oxalate
Citations are publications that use Tocris products. Selected citations for PTAC oxalate include:
Wang et al (2017) The Analgesic Effects of (5R,6R)6-(3-Propylthio-1,2,5-thiadiazol-4-yl)-1-azabicyclo[3.2.1] Octane on a Mouse Model of Neuropathic Pain. Anesth Analg 124 1330 PMID: 28002166
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