Submit a Review & Earn an Amazon Gift Card
You can now submit reviews for your favorite Tocris products. Your review will help other researchers decide on the best products for their research. Why not submit a review today?!
Submit ReviewPU 23
Description: Multidrug resistance protein (MRP) 4 inhibitor
Chemical Name: N-[[[4-[[(Phenylmethyl)amino]sulfonyl]phenyl]amino]thioxomethyl]benzamide
Purity: ≥98% (HPLC)
Biological Activity for PU 23
PU 23 is a multidrug resistance protein (MRP) 4 inhibitor. Sensitizes MRP4-overexpressing cells to the anticancer agent 6-Mercaptopurine (Cat. No. 4103; 6-MP) (IC50 values are 14.11 and 6.06 μM in the absence and presence of compound, respectively). Increases accumulation of 6-MP in MRP4-overexpressing cells.
Technical Data for PU 23
| M. Wt | 425.52 |
| Formula | C21H19N3O3S2 |
| Storage | Store at -20°C |
| Purity | ≥98% (HPLC) |
| CAS Number | 817635-93-1 |
| PubChem ID | 4779049 |
| InChI Key | RYIRRFWVFHEXTH-UHFFFAOYSA-N |
| Smiles | O=C(NC(=S)NC1=CC=C(C=C1)[S](=O)(=O)NCC1=CC=CC=C1)C1=CC=CC=C1 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for PU 23
References for PU 23
References are publications that support the biological activity of the product.
Chen et al (2018) Discovery of novel multidrug resistance protein 4 (MRP4) inhibitors as active agents reducing resistance to anticancer drug 6-Mercaptopurine (6-MP) by structure and ligand-based virtual screening. PLoS One 13 e0205175 PMID: 30321196
View Related Products by Target
View Related Products by Product Action
Keywords: PU 23, PU 23 supplier, PU23, multidrug, resistance, protein, 4, MRP4, inhibitor, inhibits, ABCC4, Multidrug, Transporters, 6885, Tocris Bioscience
Citations for PU 23
Citations are publications that use Tocris products.
Currently there are no citations for PU 23.
Reviews for PU 23
There are currently no reviews for this product. Be the first to review PU 23 and earn rewards!
Have you used PU 23?
Submit a review and receive an Amazon gift card.
$25/€18/£15/$25CAN/¥75 Yuan/¥2500 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image
Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
Programmed Cell Death Poster
There are two currently recognized forms of programmed cell death: apoptosis and necroptosis. This poster summarizes the signaling pathways involved in apoptosis, necroptosis and cell survival following death receptor activation, and highlights the influence of the molecular switch, cFLIP, on cell fate.