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Description: α6β3γ2-selective GABAA positive allosteric modulator
Alternative Names: Compound 6
Chemical Name: 2,5-Dihydro-7-methoxy-2-(4-methoxyphenyl)-3H-pyrazolo[4,3-c]quinolin-3-one
Purity: ≥98% (HPLC)
Biological Activity for PZ-II-029
PZ-II-029 is a GABAA positive allosteric modulator. Selectively binds with high affinity to α6β3γ2 subunit-containing channels. Inhibits central and peripheral trigeminal responses in a rat migraine model.
Technical Data for PZ-II-029
| M. Wt | 321.33 |
| Formula | C18H15N3O3 |
| Storage | Store at +4°C |
| Purity | ≥98% (HPLC) |
| CAS Number | 164025-44-9 |
| PubChem ID | 10426200 |
| InChI Key | CGOOCGJMECBDCB-UHFFFAOYSA-N |
| Smiles | O=C1C2=CNC3=CC(OC)=CC=C3C2=NN1C(C=C4)=CC=C4OC |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for PZ-II-029
References for PZ-II-029
References are publications that support the biological activity of the product.
Varagic et al (2013) Subtype selectivity of α+β- site ligands of GABAA receptors: identification of the first highly specific positive modulators at α6β2/3γ2 receptors. Br.J.Pharmacol. 169 384 PMID: 23472935
Fan et al (2018) The α6 subunit-containing GABAA receptor: A novel drug target for inhibition of trigeminal activation. Neuropharmacology. 140 1 PMID: 30016665
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Keywords: PZ-II-029, PZ-II-029 supplier, GABAA, modulators, modulates, selective, high, affinity, alpha6beta3gamma2, a6b3g2, α6β3γ2, migraine, Compound, 6, Receptors, 6192, Tocris Bioscience
Citations for PZ-II-029
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Currently there are no citations for PZ-II-029.
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