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Description: Glutamate dehydrogenase (GDH1) inhibitor
Chemical Name: 1-Hydroxy-2-(2-propen-1-yl)-9,10-anthracenedione
Purity: ≥98% (HPLC)
Biological Activity for R162
R162 is a glutamate dehydrogenase (GHD1) inhibitor (IC50 = 23 μM). Decreases fumarate and ROS levels, attenuates glutathione peroxidase levels and inhibits cell proliferation in cancer cell lines. Attenuates viability of a range of cancer cell lines.
Technical Data for R162
| M. Wt | 264.28 |
| Formula | C17H12O3 |
| Storage | Store at -20°C |
| Purity | ≥98% (HPLC) |
| CAS Number | 64302-87-0 |
| PubChem ID | 4412951 |
| InChI Key | IMUBGIOLZQTIGI-UHFFFAOYSA-N |
| Smiles | OC1=C2C(C3=CC=CC=C3C(C2=CC=C1CC=C)=O)=O |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for R162
References for R162
References are publications that support the biological activity of the product.
Jin et al (2015) Glutamate dehydrogenase 1 signals through antioxidant glutathione peroxidase 1 to regulate redox homeostasis and tumor growth. Cancer Cell. 27 257 PMID: 25670081
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Keywords: R162, R162 supplier, glutamate, dehydrogenase, inhibitor, inhibits, GDH1, Other, Dehydrogenases, 6054, Tocris Bioscience
Citations for R162
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Currently there are no citations for R162.
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