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Submit ReviewRaclopride
Description: Potent and selective D2 and D3 antagonist
Chemical Name: 3,5-Dichloro-N-[[(2S)-1-ethyl-2-pyrrolidinyl]methyl]-2-hydroxy-6-methoxybenzamide
Purity: ≥98% (HPLC)
Biological Activity for Raclopride
Raclopride is a selective and potent dopamine D2/D3 receptor antagonist (Ki values are 1.8, 3.5, 2400 and 18000 nM for D2, D3, D4 and D1 receptors respectively). Centrally active following systemic administration in vivo.
Compound Libraries for Raclopride
Raclopride is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.
Technical Data for Raclopride
| M. Wt | 347.24 |
| Formula | C15H20Cl2N2O3 |
| Storage | Store at -20°C |
| Purity | ≥98% (HPLC) |
| CAS Number | 84225-95-6 |
| PubChem ID | 3033769 |
| InChI Key | WAOQONBSWFLFPE-VIFPVBQESA-N |
| Smiles | ClC1=C(OC)C(C(NC[C@H]2N(CC)CCC2)=O)=C(O)C(Cl)=C1 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for Raclopride
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 34.72 | 100 | |
| ethanol | 8.68 | 25 |
Preparing Stock Solutions for Raclopride
The following data is based on the product molecular weight 347.24. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.88 mL | 14.4 mL | 28.8 mL |
| 5 mM | 0.58 mL | 2.88 mL | 5.76 mL |
| 10 mM | 0.29 mL | 1.44 mL | 2.88 mL |
| 50 mM | 0.06 mL | 0.29 mL | 0.58 mL |
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Product Datasheets for Raclopride
References for Raclopride
References are publications that support the biological activity of the product.
Hall et al (1989) Animal pharmacology of raclopride, a selective DA D2 antagonist. Psychopharmacol.Ser. 7 123 PMID: 2687851
Ogren et al (1986) The selective DA D2 receptor antagonist raclopride discriminates between DA-mediated motor functions. Psychopharmacology 90 287 PMID: 2947255
Seeman and Van Tol (1994) DA receptor pharmacology. TiPS 15 264 PMID: 7940991
If you know of a relevant reference for Raclopride, please let us know.
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Keywords: Raclopride, Raclopride supplier, Potent, selective, D2/D3, antagonists, Dopamine, D2-like, Non-Selective, Receptors, dopaminergic, Non-selective, 1810, Tocris Bioscience
12 Citations for Raclopride
Citations are publications that use Tocris products. Selected citations for Raclopride include:
Scardochio et al (2015) The Effects of Electrical and Optical Stimulation of Midbrain DArgic Neurons on Rat 50-kHz Ultrasonic Vocalizations. Front Behav Neurosci 9 331 PMID: 26696851
Liu et al (2008) Increased DA level enhances male-male courtship in Drosophila. Int J Neuropsychopharmacol 28 5539 PMID: 18495888
Zheng et al (2014) Attenuated DArgic tone in the paraventricular nucleus contributing to sympathoexcitation in rats with Type 2 diabetes. J Neurosci 306 R138 PMID: 24305061
Guo (2017) DA D4 receptor activation restores CA1 LTP in hippocampal slices from aged mice. Aging Cell 16 1323 PMID: 28975698
Ahmadiantehrani and Ron (2013) DA D2 receptor activation leads to an up-regulation of glial cell line-derived neurotrophic factor via Gβγ-Erk1/2-dependent induction of Zif268. J Neurochem PMID: 23373701
Huang et al (2009) Repeated cocaine administration decreases 5-HT(2A) receptor-mediated serotonergic enhancement of synaptic activity in rat medial prefrontal cortex. Neuropsychopharmacology 34 1979 PMID: 19212317
Ogata et al (2012) DA and full-field illumination activate D1 and D2-D5-type receptors in adult rat retinal ganglion cells. J Comp Neurol 520 4032 PMID: 22678972
Verharen et al (2019) Differential contributions of striatal dopamine D1 and D2 receptors to component processes of value-based decision making. Neuropsychopharmacology 44 2195 PMID: 31254972
Lassus et al (2018) Glutamatergic and dopaminergic modulation of cortico-striatal circuits probed by dynamic calcium imaging of networks reconstructed in microfluidic chips. Sci Rep 8 17461 PMID: 30498197
Jiang et al (2015) SKF83959 produces antidepressant effects in a chronic social defeat stress model of depression through BDNF-TrkB pathway. Psychopharmacology (Berl) 18 PMID: 25522427
Heath et al (2015) Motivational assessment of mice using the touchscreen operant testing system: effects of DArgic drugs. Psychopharmacology (Berl) 232 4043 PMID: 26156636
Chiodi et al (2014) Cocaine-induced changes of synaptic transmission in the striatum are modulated by adenosine A2A receptors and involve the tyrosine phosphatase STEP. Neuropsychopharmacology 39 569 PMID: 23989619
Do you know of a great paper that uses Raclopride from Tocris? Please let us know.
Reviews for Raclopride
Average Rating: 5 (Based on 1 Review.)
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Works as intended.
By
Anonymous on 05/14/2019
Assay Type: In Vivo
Species: Mouse
Used at a range of doses to block dopamine D2 receptors in vivo to test effect on alcohol-cue learning and seeking behavior. Drug performed well and although didn't impact place preference it did have a clear effect in that it dose-dependently decrease locomotor activity.
Literature in this Area
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Written by Phillip Strange and revised by Kim Neve in 2013, this review summarizes the history of the dopamine receptors and provides an overview of individual receptor subtype properties, their distribution and identifies ligands which act at each receptor subtype. Compounds available from Tocris are listed.
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