Submit a Review & Earn an Amazon Gift Card
You can now submit reviews for your favorite Tocris products. Your review will help other researchers decide on the best products for their research. Why not submit a review today?!
Submit ReviewRanitidine hydrochloride
Discontinued Product
1967 has been discontinued.
View all Histamine H<sub>2</sub> Receptors products.
Description: Selective H2 antagonist
Chemical Name: N-[2-[[[5-[(Dimethylamino)methyl]-2-furanyl]methyl]thio]ethyl]-N'-methyl-2-nitro-1,1-ethanediamine hydrochloride
Purity: ≥99% (HPLC)
Biological Activity for Ranitidine hydrochloride
Ranitidine hydrochloride is a potent, selective and competitive histamine H2 receptor antagonist (pA2 = 6.95 - 7.2). Inhibits gastric acid secretion induced by histamine, pentagastrin, bethanecol and food in vivo. Also inhibits aspirin-induced gastric lesions.
Technical Data for Ranitidine hydrochloride
| M. Wt | 350.86 |
| Formula | C13H22N4O3S.HCl |
| Storage | Desiccate at +4°C |
| Purity | ≥99% (HPLC) |
| CAS Number | 66357-59-3 |
| PubChem ID | 657344 |
| InChI Key | GGWBHVILAJZWKJ-CHHCPSLASA-N |
| Smiles | Cl[H].CN\C(NCCSCC1=CC=C(CN(C)C)O1)=C\N(=O)=O |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for Ranitidine hydrochloride
References for Ranitidine hydrochloride
References are publications that support the biological activity of the product.
Daly et al (1981) Some in vitro and in vivo actions of the new histamine H2-receptor antagonist, ranitidine. Br.J.Pharmacol. 72 49 PMID: 6112034
Daly et al (1981) Antagonism of vasodepressor and gastric secretory responses to histamine by the H2-receptor antagonists, ranitidine and cimetidine, in the anaesthetized dog. Br.J.Pharmacol. 72 55 PMID: 6112035
Brittain and Daly (1981) A review of the animal pharmacology of ranitidine - a new, selective histamine H2-antagonist. Scand.J.Gastroenterol.Suppl. 69 1
View Related Products by Target
View Related Products by Product Action
Keywords: Ranitidine hydrochloride, Ranitidine hydrochloride supplier, Selective, H2, antagonists, receptors, histamine, histaminergic, h2, antagonist, Histamine, Receptors, 1967, Tocris Bioscience
1 Citation for Ranitidine hydrochloride
Citations are publications that use Tocris products. Selected citations for Ranitidine hydrochloride include:
Kwiatkowski et al (2013) Coordination of distinct but interacting rhythmic motor programs by a modulatory projection neuron using different co-transmitters in different ganglia. J Exp Biol 216 1827 PMID: 23393282
Reviews for Ranitidine hydrochloride
There are currently no reviews for this product. Be the first to review Ranitidine hydrochloride and earn rewards!
Have you used Ranitidine hydrochloride?
Submit a review and receive an Amazon gift card.
$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image
$25/€18/£15/$25CAN/¥75 Yuan/¥2500 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image
Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
Histamine Receptors Scientific Review
Written by Iwan de Esch and Rob Leurs, this review provides a synopsis of the different histamine receptor subtypes and the ligands that act upon them; compounds available from Tocris are listed.