Resiniferatoxin

Name: Resiniferatoxin
Brand: Tocris Bioscience
SKU: 1137

Cat. No. 1137 5 Citations Submit a Review Datasheet / COA / SDS

Discontinued Product

1137 has been discontinued.

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Description: Potent vanilloid receptor agonist

Chemical Name: 4-Hydroxy-3-methoxy-[(2S,3aR,3bS,6aR,9aR,9bR,10R,11aR)-3a,3b,6,6a,9a,10,11,11a-octahydro-6a-hydroxy-8,10-dimethyl-11a-(1-methylethenyl)-7-oxo-2-(phenylmethyl)-7H-2,9b-epoxyazuleno[5,4-e]-1,3-benzodioxol-5-yl]benzeneacetate

Purity: ≥98% (HPLC)

Datasheet

Citations (5)

Reviews

Biological Activity Technical Data Datasheets References

Biological Activity for Resiniferatoxin

Potent analog of capsaicin that is an agonist at vanilloid receptors (K_i = 43 pM). Like capsaicin, it acts as a selective modulator of primary afferent neurons.

Technical Data for Resiniferatoxin

M. Wt	628.72
Formula	C₃₇H₄₀O₉
Storage	Desiccate at -20°C
Purity	≥98% (HPLC)
CAS Number	57444-62-9
PubChem ID	5702546
InChI Key	DSDNAKHZNJAGHN-MXTYGGKSSA-N
Smiles	O=C1C(C)=C[C@]2([H])[C@@](O)1CC(COC(CC5=CC(OC)=C(O)C=C5)=O)=C[C@]3([H])[C@@](O6)2[C@H](C)C[C@@]4([C@@](C)=C)[C@@]([H])3O[C@]6(CC7=CC=CC=C7)O4

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Product Datasheets for Resiniferatoxin

Certificate of Analysis / Product Datasheet

Safety Datasheet

References for Resiniferatoxin

References are publications that support the biological activity of the product.

Acs et al (1996) Distinct structure-activity relations for stimulation of ⁴⁵Ca uptake and for high affinity binding in cultured rat dorsal root ganglion neurons and dorsal root ganglion membranes. Brain Res.Mol.Brain Res. 35 173 PMID: 8717353

Szolcsanyi et al (1990) Resiniferatoxin: an ultrapotent selective modulator of capsaicin-sensitive primary afferent neurons. J.Pharmacol.Exp.Ther. 255 923 PMID: 2243359

Winter et al (1990) Cellular mechanism of action of resiniferatoxin: a potent sensory neuron excitotoxin. Brain Res. 520 131 PMID: 2169951

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