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Submit ReviewRJR 2429 dihydrochloride
Discontinued Product
1271 has been discontinued.
View all Nicotinic Receptors (Non-selective) products.
Description: nAChR agonist; displays selectivity for α4β2, α1βγδ and α3β4 subtypes
Chemical Name: (±)-2-(3-Pyridinyl)-1-azabicyclo[2.2.2]octane dihydrochloride
Purity: ≥98% (HPLC)
Biological Activity for RJR 2429 dihydrochloride
RJR 2429 dihydrochloride is a potent nAChR agonist that displays selectivity for α4β2 (Ki = 1 nM) and α1βγδ subtypes (EC50 values are 297 and 55 nM respectively). Induces dopamine release from striatal neurons (EC50 = 2 nM) and inhibits ion flux in thalamic neurons (IC50 = 154 nM). Also putative α3β4 agonist that potentiates catecholamine release.
Technical Data for RJR 2429 dihydrochloride
| M. Wt | 261.19 |
| Formula | C12H16N2.2HCl |
| Storage | Desiccate at RT |
| Purity | ≥98% (HPLC) |
| CAS Number | 1021418-53-0 |
| PubChem ID | 56972204 |
| InChI Key | PIUNXHHZRIUBOV-UHFFFAOYSA-N |
| Smiles | C1(C2N3CCC(CC3)C2)=CC=CN=C1.Cl.Cl |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for RJR 2429 dihydrochloride
References for RJR 2429 dihydrochloride
References are publications that support the biological activity of the product.
Bencherif et al (1998) The heterocyclic substituted pyridine derivative (±)-2-(3-pyridinyl)-1-azabicyclo[2.2.2]octane (RJR-2429): a selective ligand at nicotinic acetylcholine receptors. J.Pharmacol.Exp.Ther. 284 886 PMID: 9495846
Bhatti et al (2008) Synthesis of 2-(pyridin-3-yl)-1-azabicyclo[3.2.2]nonane, 2-(pyridin-3-yl)-1-azabicyclo[2.2.2]octane, and 2-(pyridin-3-yl)-1-azabicyclo[3.2.1]octane, a class of potent nicotinic acetylcholine receptor-ligands. J.Org.Chem. 73 3497 PMID: 18363376
Yokotani et al (2002) Characterization of functional nicotinic acetylcholine receptors involved in catecholamine release from isolated rat adrenal gland. Eur.J.Pharmacol. 446 83 PMID: 12098588
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Keywords: RJR 2429 dihydrochloride, RJR 2429 dihydrochloride supplier, Nicotinic, receptor, agonists, Acetylcholine, Receptors, Non-Selective, Subtypes, nAChR, RJR2429, dihydrochloride, (Non-selective), 1271, Tocris Bioscience
Citations for RJR 2429 dihydrochloride
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Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
Nicotinic ACh Receptors Scientific Review
Updated in 2014, this review by Sue Wonnacott summarizes the diverse structure and function of nicotinic acetylcholine receptors and gives an in-depth review of the ligands available for nAChR research. Compounds available from Tocris are listed.